STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ACN13724.1Bifunctional homocysteine S-methyltransferase / 5,10-methylenetetrahydrofolate reductase protein; Belongs to the methylenetetrahydrofolate reductase family. (274 aa)    
Predicted Functional Partners:
ACN17453.1
Methionine synthase I, cobalamin-binding domain protein.
 
 0.997
metH2
MetH2; vitamin-B12 dependent methionine synthase MetH (5-methyltetrahydrofolate--homocysteine methyltransferase).
 
 
 0.955
glyA
GlyA; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.931
fhs
Fhs; Formate--tetrahydrofolate ligase Fhs (Formyltetrahydrofolate synthetase) (FTHFS).
  
 
 0.917
folD
FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
    
 0.914
gcvT
GcvT; Glycine cleavage system, aminomethyltransferase protein GvcT; Belongs to the GcvT family.
  
 
 0.913
ACN17658.1
Putative glycine cleavage system T protein (aminomethyltransferase); Belongs to the GcvT family.
  
 
 0.913
thyX
ThyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
     
 0.906
metH3
MetH3; vitamin-B12 dependent methionine synthase MetH (5-methyltetrahydrofolate--homocysteine methyltransferase).
 
 
 0.785
metH1
MetH1; vitamin-B12 dependent methionine synthase MetH (5-methyltetrahydrofolate--homocysteine methyltransferase).
 
 
 0.775
Your Current Organism:
Desulfobacterium autotrophicum
NCBI taxonomy Id: 177437
Other names: D. autotrophicum HRM2, Desulfobacterium autotrophicum HRM2, Desulfobacterium autotrophicum str. HRM2, Desulfobacterium autotrophicum strain HRM2
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