ACN13943.1 protein (Desulfobacterium autotrophicum)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

ACN13943.1

ABC-type transporter, permease protein. (599 aa)

Predicted Functional Partners:

ACN13942.1

0.961

ACN13945.1

0.953

ACN13944.1

0.940

ACN13940.1

0.933

ACN13941.1

0.768

ctpA1

0.691

ACN13939.1

0.691

ACN13696.1

0.580

ACN14739.1

0.580

lolD2

0.580

Your Current Organism:

Desulfobacterium autotrophicum

NCBI taxonomy Id: 177437
Other names: D. autotrophicum HRM2, Desulfobacterium autotrophicum HRM2, Desulfobacterium autotrophicum str. HRM2, Desulfobacterium autotrophicum strain HRM2

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACN13696.1	ACN13943.1	HRM2_05820	HRM2_08300	Predicted ABC-type transporter, ATP-binding protein.	ABC-type transporter, permease protein.	0.580
ACN13939.1	ACN13940.1	HRM2_08260	HRM2_08270	Serine/threonine-protein kinase MRCK alpha (CDC42-binding protein kinase alpha).	Hypothetical protein.	0.765
ACN13939.1	ACN13941.1	HRM2_08260	HRM2_08280	Serine/threonine-protein kinase MRCK alpha (CDC42-binding protein kinase alpha).	Hypothetical protein.	0.664
ACN13939.1	ACN13942.1	HRM2_08260	HRM2_08290	Serine/threonine-protein kinase MRCK alpha (CDC42-binding protein kinase alpha).	Conserved hypothetical protein.	0.683
ACN13939.1	ACN13943.1	HRM2_08260	HRM2_08300	Serine/threonine-protein kinase MRCK alpha (CDC42-binding protein kinase alpha).	ABC-type transporter, permease protein.	0.691
ACN13939.1	ACN13944.1	HRM2_08260	HRM2_08310	Serine/threonine-protein kinase MRCK alpha (CDC42-binding protein kinase alpha).	ABC-type transporter, ATP-binding protein.	0.672
ACN13939.1	ACN13945.1	HRM2_08260	HRM2_08320	Serine/threonine-protein kinase MRCK alpha (CDC42-binding protein kinase alpha).	Predicted serine/threonine protein kinase PpkA.	0.700
ACN13939.1	ctpA1	HRM2_08260	HRM2_08250	Serine/threonine-protein kinase MRCK alpha (CDC42-binding protein kinase alpha).	CtpA1; Carboxy-terminal processing protease CtpA [precursor].	0.782
ACN13940.1	ACN13939.1	HRM2_08270	HRM2_08260	Hypothetical protein.	Serine/threonine-protein kinase MRCK alpha (CDC42-binding protein kinase alpha).	0.765
ACN13940.1	ACN13941.1	HRM2_08270	HRM2_08280	Hypothetical protein.	Hypothetical protein.	0.701
ACN13940.1	ACN13942.1	HRM2_08270	HRM2_08290	Hypothetical protein.	Conserved hypothetical protein.	0.902
ACN13940.1	ACN13943.1	HRM2_08270	HRM2_08300	Hypothetical protein.	ABC-type transporter, permease protein.	0.933
ACN13940.1	ACN13944.1	HRM2_08270	HRM2_08310	Hypothetical protein.	ABC-type transporter, ATP-binding protein.	0.758
ACN13940.1	ACN13945.1	HRM2_08270	HRM2_08320	Hypothetical protein.	Predicted serine/threonine protein kinase PpkA.	0.928
ACN13940.1	ctpA1	HRM2_08270	HRM2_08250	Hypothetical protein.	CtpA1; Carboxy-terminal processing protease CtpA [precursor].	0.744
ACN13941.1	ACN13939.1	HRM2_08280	HRM2_08260	Hypothetical protein.	Serine/threonine-protein kinase MRCK alpha (CDC42-binding protein kinase alpha).	0.664
ACN13941.1	ACN13940.1	HRM2_08280	HRM2_08270	Hypothetical protein.	Hypothetical protein.	0.701
ACN13941.1	ACN13942.1	HRM2_08280	HRM2_08290	Hypothetical protein.	Conserved hypothetical protein.	0.768
ACN13941.1	ACN13943.1	HRM2_08280	HRM2_08300	Hypothetical protein.	ABC-type transporter, permease protein.	0.768
ACN13941.1	ACN13944.1	HRM2_08280	HRM2_08310	Hypothetical protein.	ABC-type transporter, ATP-binding protein.	0.768

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

12

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0071973

Bacterial-type flagellum-dependent cell motility

6 of 19

1.97

3.21

6.14e-08

GO:0006935

Chemotaxis

3 of 7

2.1

1.58

0.00087

GO:0044781

Bacterial-type flagellum organization

3 of 12

1.87

1.35

0.0020

GO:0009306

Protein secretion

3 of 14

1.8

1.27

0.0027

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003774

Cytoskeletal motor activity

5 of 7

2.32

3.56

8.39e-08

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009288

Bacterial-type flagellum

9 of 23

2.06

5.81

1.66e-15

GO:0009425

Bacterial-type flagellum basal body

8 of 17

2.14

5.76

2.31e-14

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3168

Cilium

10 of 17

2.24

7.48

1.21e-18

CL:3165

Cilium, and Proton channel activity

11 of 36

1.96

6.06

1.21e-18

CL:3191

Cytoskeletal motor activity

5 of 5

2.47

4.33

3.20e-09

CL:3169

Flagellar basal body rod FlgEFG protein C-terminal, and Bacterial-type flagellum assembly

4 of 11

2.03

2.48

7.19e-06

CL:3181

Bacterial flagellum protein export, and Bacterial-type flagellum assembly

2 of 5

2.07

0.97

0.0150

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

otm02040

Flagellar assembly

8 of 25

1.98

4.76

7.65e-13

otm02030

Bacterial chemotaxis

2 of 6

1.99

0.95

0.0154

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0009288

Bacterial-type flagellum

9 of 28

1.98

5.21

1.67e-14

GOCC:0009425

Bacterial-type flagellum basal body

7 of 18

2.06

4.58

1.89e-11

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0282

Flagellum

8 of 25

1.98

4.68

1.47e-12

KW-0975

Bacterial flagellum

3 of 9

1.99

1.75

0.00032

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01052

Type III flagellar switch regulator (C-ring) FliN C-term

2 of 2

2.47

0.84

0.0298

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