ACN14238.1 protein (Desulfobacterium autotrophicum)

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second shell of interactors

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proteins of unknown 3D structure

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Edges:

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

ACN14238.1

Conserved hypothetical protein. (354 aa)

Predicted Functional Partners:

ACN14239.1

0.989

ACN17758.1

0.842

ACN13135.1

0.672

ACN17596.1

0.656

Your Current Organism:

Desulfobacterium autotrophicum

NCBI taxonomy Id: 177437
Other names: D. autotrophicum HRM2, Desulfobacterium autotrophicum HRM2, Desulfobacterium autotrophicum str. HRM2, Desulfobacterium autotrophicum strain HRM2

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACN13135.1	ACN14238.1	HRM2_00120	HRM2_11260	SWI/SNF helicase family protein.	Conserved hypothetical protein.	0.672
ACN14238.1	ACN13135.1	HRM2_11260	HRM2_00120	Conserved hypothetical protein.	SWI/SNF helicase family protein.	0.672
ACN14238.1	ACN14239.1	HRM2_11260	HRM2_11270	Conserved hypothetical protein.	SNF2-related helicase.	0.989
ACN14238.1	ACN17596.1	HRM2_11260	HRM2_45400	Conserved hypothetical protein.	Helicase, Snf2 family.	0.656
ACN14238.1	ACN17758.1	HRM2_11260	HRM2_47090	Conserved hypothetical protein.	Putative helicase.	0.842
ACN14239.1	ACN14238.1	HRM2_11270	HRM2_11260	SNF2-related helicase.	Conserved hypothetical protein.	0.989
ACN17596.1	ACN14238.1	HRM2_45400	HRM2_11260	Helicase, Snf2 family.	Conserved hypothetical protein.	0.656
ACN17758.1	ACN14238.1	HRM2_47090	HRM2_11260	Putative helicase.	Conserved hypothetical protein.	0.842

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

11

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0036068

Light-independent chlorophyll biosynthetic process

5 of 6

2.47

3.89

2.73e-08

GO:0015994

Chlorophyll metabolic process

6 of 20

2.02

3.42

2.73e-08

GO:0036070

Light-independent bacteriochlorophyll biosynthetic process

4 of 5

2.45

3.15

8.95e-07

GO:0015979

Photosynthesis

6 of 27

1.89

3.14

4.34e-08

GO:0019685

Photosynthesis, dark reaction

3 of 4

2.42

2.26

5.55e-05

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016636

Oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor

3 of 3

2.54

1.96

0.00023

GO:0016730

Oxidoreductase activity, acting on iron-sulfur proteins as donors

3 of 5

2.32

1.84

0.00033

GO:0051536

Iron-sulfur cluster binding

5 of 96

1.26

1.09

0.0010

GO:0051539

4 iron, 4 sulfur cluster binding

3 of 43

1.39

0.79

0.0179

GO:0016491

Oxidoreductase activity

6 of 367

0.76

0.49

0.0179

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:29515543

(2018) Evolution of Phototrophy in the Chloroflexi Phylum Driven by Horizontal Gene Transfer.

6 of 12

2.24

4.25

1.32e-09

PMID:31396180

(2019) Evolutionary Implications of Anoxygenic Phototrophy in the Bacterial Phylum Candidatus Eremiobacterota (WPS-2).

4 of 7

2.3

2.76

4.18e-06

PMID:22628531

(2012) Origin and spread of photosynthesis based upon conserved sequence features in key bacteriochlorophyll biosynthesis proteins.

3 of 3

2.54

2.2

8.20e-05

PMID:33801086

(2021) In-Situ Metatranscriptomic Analyses Reveal the Metabolic Flexibility of the Thermophilic Anoxygenic Photosynthetic Bacterium Chloroflexus aggregans in a Hot Spring Cyanobacteria-Dominated Microbial Mat.

3 of 4

2.42

2.11

0.00011

PMID:34006650

(2021) Genomic Analysis of the Yet-Uncultured Binatota Reveals Broad Methylotrophic, Alkane-Degradation, and Pigment Production Capacities.

3 of 9

2.07

1.67

0.00054

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3881

Photosynthesis, and PucC-related

11 of 25

2.19

7.87

7.21e-21

CL:3883

Mixed, incl. Bacteriochlorophyll metabolic process, and BT1 family

10 of 19

2.27

7.77

3.05e-19

CL:3885

Bacteriochlorophyll metabolic process, and Bacteriochlorophyll/chlorophyll synthetase

6 of 12

2.24

4.62

1.56e-10

CL:3909

Mixed, incl. BT1 family, and Methyltransferase, class B

4 of 6

2.37

3.2

5.72e-07

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

cau00860

Porphyrin and chlorophyll metabolism

10 of 56

1.8

4.67

1.25e-15

cau01110

Biosynthesis of secondary metabolites

9 of 337

0.97

1.08

8.64e-07

cau01100

Metabolic pathways

10 of 670

0.72

0.68

9.16e-06

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0602

Photosynthesis

6 of 11

2.28

4.6

2.58e-10

KW-0077

Bacteriochlorophyll biosynthesis

5 of 7

2.4

4.17

5.32e-09

KW-0408

Iron

5 of 61

1.46

1.67

2.80e-05

KW-0004

4Fe-4S

3 of 28

1.57

1.15

0.0031

KW-0479

Metal-binding

5 of 240

0.86

0.59

0.0099

(more ...)

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