STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ptpSPtpS; 6-pyruvoyl tetrahydrobiopterin synthase PtpS. (127 aa)    
Predicted Functional Partners:
folE2
Conserved hypothetical protein; Converts GTP to 7,8-dihydroneopterin triphosphate.
 
  
 0.941
phoA
PhoA; Alkaline phosphatase PhoA; Belongs to the alkaline phosphatase family.
     
  0.900
dnaJ2
DnaJ2; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are [...]
       0.703
cysS2
CysS2; cysteinyl-tRNA synthetase CysS2 (Cysteine--tRNA ligase) (CysRS); Belongs to the class-I aminoacyl-tRNA synthetase family.
  
  
 0.497
guaA1
GuaA1; Catalyzes the synthesis of GMP from XMP.
     
 0.492
cysS3
CysS3; cysteinyl-tRNA synthetase CysS3 (cysteine--tRNA ligase) (CysRS).
  
  
 0.489
cysS1
CysS1; Bifunctional cysteinyl-tRNA synthetase CysS1 (Cysteine--tRNA ligase) (CysRS); Belongs to the class-I aminoacyl-tRNA synthetase family.
  
  
 0.478
thrS2
ThrS2; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr).
   
 
 0.476
ubiE3
UbiE3; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2).
     
 0.465
hisI
HisI; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
     
 0.459
Your Current Organism:
Desulfobacterium autotrophicum
NCBI taxonomy Id: 177437
Other names: D. autotrophicum HRM2, Desulfobacterium autotrophicum HRM2, Desulfobacterium autotrophicum str. HRM2, Desulfobacterium autotrophicum strain HRM2
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