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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
citCCitC; NADP-dependent isocitrate dehydrogenase CitC (Oxalosuccinate decarboxylase) (IDH). (410 aa)    
Predicted Functional Partners:
acnA
AcnA; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate.
 
 0.989
gdhA1
GdhA1; NADP-specific glutamate dehydrogenase GdhA (NADP-GDH); Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
   
 0.953
fumA
FumA; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family.
  
  
 0.935
icd
Icd; NADP-dependent isocitrate dehydrogenase Icd.
  
  
 
0.903
gltB2
GltB2; Glutamate synthase [NADPH], large chain (NADPH-GOGAT).
    
 0.896
sucC1
SucC1; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
 
  
 0.842
ACN14021.1
Putative aminohydrolase.
    
  0.837
ACN13274.1
Fumarate lyase (DEAD box).
     
 0.829
ACN16221.1
Putative aspartate/tyrosine/aromatic acid aminotransferase.
   
 0.829
ACN17828.1
Glutamate synthase; Belongs to the glutamate synthase family.
    
 0.829
Your Current Organism:
Desulfobacterium autotrophicum
NCBI taxonomy Id: 177437
Other names: D. autotrophicum HRM2, Desulfobacterium autotrophicum HRM2, Desulfobacterium autotrophicum str. HRM2, Desulfobacterium autotrophicum strain HRM2
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