node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
apt1 | apt2 | HRM2_05200 | HRM2_38820 | Apt1; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Apt2; Adenine phosphoribosyltransferase Apt. | 0.900 |
apt1 | gmk | HRM2_05200 | HRM2_18460 | Apt1; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Gmk; Essential for recycling GMP and indirectly, cGMP. | 0.955 |
apt1 | guaA1 | HRM2_05200 | HRM2_18870 | Apt1; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | GuaA1; Catalyzes the synthesis of GMP from XMP. | 0.990 |
apt1 | purD | HRM2_05200 | HRM2_09300 | Apt1; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | PurD; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR); Belongs to the GARS family. | 0.770 |
apt1 | pyrG | HRM2_05200 | HRM2_26840 | Apt1; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | PyrG; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.487 |
apt1 | xpt | HRM2_05200 | HRM2_02560 | Apt1; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Xpt; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.900 |
apt2 | apt1 | HRM2_38820 | HRM2_05200 | Apt2; Adenine phosphoribosyltransferase Apt. | Apt1; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.900 |
apt2 | gmk | HRM2_38820 | HRM2_18460 | Apt2; Adenine phosphoribosyltransferase Apt. | Gmk; Essential for recycling GMP and indirectly, cGMP. | 0.955 |
apt2 | guaA1 | HRM2_38820 | HRM2_18870 | Apt2; Adenine phosphoribosyltransferase Apt. | GuaA1; Catalyzes the synthesis of GMP from XMP. | 0.990 |
apt2 | purD | HRM2_38820 | HRM2_09300 | Apt2; Adenine phosphoribosyltransferase Apt. | PurD; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR); Belongs to the GARS family. | 0.770 |
apt2 | pyrG | HRM2_38820 | HRM2_26840 | Apt2; Adenine phosphoribosyltransferase Apt. | PyrG; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.487 |
apt2 | xpt | HRM2_38820 | HRM2_02560 | Apt2; Adenine phosphoribosyltransferase Apt. | Xpt; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.900 |
argS | gmk | HRM2_31550 | HRM2_18460 | ArgS; arginyl-tRNA synthetase ArgS (arginine--tRNA ligase) (ArgRS). | Gmk; Essential for recycling GMP and indirectly, cGMP. | 0.608 |
argS | guaA1 | HRM2_31550 | HRM2_18870 | ArgS; arginyl-tRNA synthetase ArgS (arginine--tRNA ligase) (ArgRS). | GuaA1; Catalyzes the synthesis of GMP from XMP. | 0.988 |
argS | guaB | HRM2_31550 | HRM2_24800 | ArgS; arginyl-tRNA synthetase ArgS (arginine--tRNA ligase) (ArgRS). | GuaB; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.425 |
argS | pyrG | HRM2_31550 | HRM2_26840 | ArgS; arginyl-tRNA synthetase ArgS (arginine--tRNA ligase) (ArgRS). | PyrG; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.876 |
argS | rplK | HRM2_31550 | HRM2_36360 | ArgS; arginyl-tRNA synthetase ArgS (arginine--tRNA ligase) (ArgRS). | RplK; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. | 0.654 |
gmk | apt1 | HRM2_18460 | HRM2_05200 | Gmk; Essential for recycling GMP and indirectly, cGMP. | Apt1; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.955 |
gmk | apt2 | HRM2_18460 | HRM2_38820 | Gmk; Essential for recycling GMP and indirectly, cGMP. | Apt2; Adenine phosphoribosyltransferase Apt. | 0.955 |
gmk | argS | HRM2_18460 | HRM2_31550 | Gmk; Essential for recycling GMP and indirectly, cGMP. | ArgS; arginyl-tRNA synthetase ArgS (arginine--tRNA ligase) (ArgRS). | 0.608 |