STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
lpdALpdA; Lipoamide dehydrogenase LpdA (pyruvate dehydrogenase complex, E3 component). (477 aa)    
Predicted Functional Partners:
pdhC
PdhC; Dihydrolipoamide acetyltransferase PdhC (pyruvate dehydrogenase complex, E2 component).
 0.999
gcvH
GcvH; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
 
  
 0.988
gcvT
GcvT; Glycine cleavage system, aminomethyltransferase protein GvcT; Belongs to the GcvT family.
 
 0.983
gcvP2
GcvP2; Glycine cleavage system, dehydrogenase subunit GcvP2.
 
 
 0.975
gcvP1
GcvP1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
 
 
 0.975
ACN17658.1
Putative glycine cleavage system T protein (aminomethyltransferase); Belongs to the GcvT family.
 
 0.969
pdhB
PdhB; Pyruvate dehydrogenase complex, beta subunit PdhB (E1 component).
 0.959
acoB
AcoB; Acetoin dehydrogenase E1, beta subunit AcoB.
 0.949
glyA
GlyA; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
 
 0.934
ACN13842.1
Dihydrolipoyl dehydrogenase (E3 component of pyruvate and 2-oxoglutarate dehydrogenases complexes).
  
  
 
0.928
Your Current Organism:
Desulfobacterium autotrophicum
NCBI taxonomy Id: 177437
Other names: D. autotrophicum HRM2, Desulfobacterium autotrophicum HRM2, Desulfobacterium autotrophicum str. HRM2, Desulfobacterium autotrophicum strain HRM2
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