node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACN14057.1 | ligA1 | HRM2_09450 | HRM2_28100 | Predicted death-on-curing family protein. | LigA1; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. | 0.734 |
ACN17767.1 | leuS | HRM2_47180 | HRM2_27190 | Putative ATP-dependent DNA helicase. | LeuS; leucyl-tRNA synthetase LeuS (Leucine--tRNA ligase); Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.739 |
ACN17767.1 | ligA1 | HRM2_47180 | HRM2_28100 | Putative ATP-dependent DNA helicase. | LigA1; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. | 0.837 |
ACN17767.1 | ligA2 | HRM2_47180 | HRM2_32340 | Putative ATP-dependent DNA helicase. | LigA2; DNA ligase LigA (Polydeoxyribonucleotide synthase). | 0.606 |
ACN17767.1 | pcrA1 | HRM2_47180 | HRM2_40570 | Putative ATP-dependent DNA helicase. | PcrA1; ATP-dependent DNA helicase PcrA. | 0.781 |
ACN17767.1 | polA | HRM2_47180 | HRM2_12370 | Putative ATP-dependent DNA helicase. | PolA; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.984 |
ACN17767.1 | recO | HRM2_47180 | HRM2_28160 | Putative ATP-dependent DNA helicase. | RecO; Involved in DNA repair and RecF pathway recombination. | 0.480 |
ACN17767.1 | rsmB | HRM2_47180 | HRM2_27010 | Putative ATP-dependent DNA helicase. | RsmB; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | 0.735 |
ACN17767.1 | ruvB | HRM2_47180 | HRM2_30510 | Putative ATP-dependent DNA helicase. | RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. | 0.550 |
ACN17767.1 | topA | HRM2_47180 | HRM2_27270 | Putative ATP-dependent DNA helicase. | TopA; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally [...] | 0.978 |
leuS | ACN17767.1 | HRM2_27190 | HRM2_47180 | LeuS; leucyl-tRNA synthetase LeuS (Leucine--tRNA ligase); Belongs to the class-I aminoacyl-tRNA synthetase family. | Putative ATP-dependent DNA helicase. | 0.739 |
leuS | ligA1 | HRM2_27190 | HRM2_28100 | LeuS; leucyl-tRNA synthetase LeuS (Leucine--tRNA ligase); Belongs to the class-I aminoacyl-tRNA synthetase family. | LigA1; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. | 0.900 |
leuS | polA | HRM2_27190 | HRM2_12370 | LeuS; leucyl-tRNA synthetase LeuS (Leucine--tRNA ligase); Belongs to the class-I aminoacyl-tRNA synthetase family. | PolA; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.657 |
leuS | topA | HRM2_27190 | HRM2_27270 | LeuS; leucyl-tRNA synthetase LeuS (Leucine--tRNA ligase); Belongs to the class-I aminoacyl-tRNA synthetase family. | TopA; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally [...] | 0.936 |
ligA1 | ACN14057.1 | HRM2_28100 | HRM2_09450 | LigA1; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. | Predicted death-on-curing family protein. | 0.734 |
ligA1 | ACN17767.1 | HRM2_28100 | HRM2_47180 | LigA1; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. | Putative ATP-dependent DNA helicase. | 0.837 |
ligA1 | leuS | HRM2_28100 | HRM2_27190 | LigA1; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. | LeuS; leucyl-tRNA synthetase LeuS (Leucine--tRNA ligase); Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.900 |
ligA1 | ligA2 | HRM2_28100 | HRM2_32340 | LigA1; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. | LigA2; DNA ligase LigA (Polydeoxyribonucleotide synthase). | 0.936 |
ligA1 | pcrA1 | HRM2_28100 | HRM2_40570 | LigA1; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. | PcrA1; ATP-dependent DNA helicase PcrA. | 0.727 |
ligA1 | polA | HRM2_28100 | HRM2_12370 | LigA1; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. | PolA; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.785 |