prkA2 protein (Desulfobacterium autotrophicum)

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second shell of interactors

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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Score

prkA2

PrkA2; Serine protein kinase PrkA. (687 aa)

Predicted Functional Partners:

ACN16010.1

0.993

ACN16009.1

0.991

ACN16008.1

0.943

ACN16265.1

0.619

phoH2

0.579

glgA1

0.548

glgA2

0.548

ACN14964.1

0.532

ACN14421.1

0.518

ACN14004.1

0.460

Your Current Organism:

Desulfobacterium autotrophicum

NCBI taxonomy Id: 177437
Other names: D. autotrophicum HRM2, Desulfobacterium autotrophicum HRM2, Desulfobacterium autotrophicum str. HRM2, Desulfobacterium autotrophicum strain HRM2

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACN14004.1	ACN16008.1	HRM2_08910	HRM2_29200	Conserved hypothetical protein; Belongs to the AAA ATPase family.	Sensory box histidine kinase/response regulator protein.	0.555
ACN14004.1	ACN16009.1	HRM2_08910	HRM2_29210	Conserved hypothetical protein; Belongs to the AAA ATPase family.	SpoVR-like family protein.	0.557
ACN14004.1	ACN16010.1	HRM2_08910	HRM2_29220	Conserved hypothetical protein; Belongs to the AAA ATPase family.	Conserved hypothetical protein; Belongs to the UPF0229 family.	0.459
ACN14004.1	prkA2	HRM2_08910	HRM2_29230	Conserved hypothetical protein; Belongs to the AAA ATPase family.	PrkA2; Serine protein kinase PrkA.	0.460
ACN14421.1	ACN16008.1	HRM2_13100	HRM2_29200	Conserved hypothetical protein.	Sensory box histidine kinase/response regulator protein.	0.518
ACN14421.1	ACN16009.1	HRM2_13100	HRM2_29210	Conserved hypothetical protein.	SpoVR-like family protein.	0.722
ACN14421.1	ACN16010.1	HRM2_13100	HRM2_29220	Conserved hypothetical protein.	Conserved hypothetical protein; Belongs to the UPF0229 family.	0.467
ACN14421.1	prkA2	HRM2_13100	HRM2_29230	Conserved hypothetical protein.	PrkA2; Serine protein kinase PrkA.	0.518
ACN14964.1	ACN16008.1	HRM2_18620	HRM2_29200	Hypothetical protein.	Sensory box histidine kinase/response regulator protein.	0.547
ACN14964.1	ACN16009.1	HRM2_18620	HRM2_29210	Hypothetical protein.	SpoVR-like family protein.	0.439
ACN14964.1	ACN16010.1	HRM2_18620	HRM2_29220	Hypothetical protein.	Conserved hypothetical protein; Belongs to the UPF0229 family.	0.477
ACN14964.1	prkA2	HRM2_18620	HRM2_29230	Hypothetical protein.	PrkA2; Serine protein kinase PrkA.	0.532
ACN16008.1	ACN14004.1	HRM2_29200	HRM2_08910	Sensory box histidine kinase/response regulator protein.	Conserved hypothetical protein; Belongs to the AAA ATPase family.	0.555
ACN16008.1	ACN14421.1	HRM2_29200	HRM2_13100	Sensory box histidine kinase/response regulator protein.	Conserved hypothetical protein.	0.518
ACN16008.1	ACN14964.1	HRM2_29200	HRM2_18620	Sensory box histidine kinase/response regulator protein.	Hypothetical protein.	0.547
ACN16008.1	ACN16009.1	HRM2_29200	HRM2_29210	Sensory box histidine kinase/response regulator protein.	SpoVR-like family protein.	0.993
ACN16008.1	ACN16010.1	HRM2_29200	HRM2_29220	Sensory box histidine kinase/response regulator protein.	Conserved hypothetical protein; Belongs to the UPF0229 family.	0.991
ACN16008.1	ACN16265.1	HRM2_29200	HRM2_31840	Sensory box histidine kinase/response regulator protein.	Conserved hypothetical protein.	0.546
ACN16008.1	glgA1	HRM2_29200	HRM2_23610	Sensory box histidine kinase/response regulator protein.	GlgA1; Glycogen synthase GlgA (Starch [bacterial glycogen] synthase).	0.548
ACN16008.1	glgA2	HRM2_29200	HRM2_29000	Sensory box histidine kinase/response regulator protein.	GlgA2; Synthesizes alpha-1,4-glucan chains using ADP-glucose.	0.548

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Network Stats

number of nodes:

11

number of edges:

48

average node degree:

8.73

avg. local clustering coefficient:

0.933

expected number of edges:

12

PPI enrichment p-value:

2.55e-15

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008380

RNA splicing

5 of 219

1.44

1.16

0.0018

GO:0006397

mRNA processing

5 of 273

1.35

1.05

0.0026

GO:0000398

mRNA splicing, via spliceosome

4 of 176

1.44

0.94

0.0080

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003723

RNA binding

8 of 590

1.22

1.47

3.15e-06

GO:1901363

Heterocyclic compound binding

9 of 2786

0.6

0.41

0.0128

GO:0097159

Organic cyclic compound binding

9 of 2796

0.59

0.41

0.0128

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005681

Spliceosomal complex

5 of 145

1.62

1.78

5.51e-05

GO:0071013

Catalytic step 2 spliceosome

3 of 63

1.76

1.28

0.0023

GO:0071014

post-mRNA release spliceosomal complex

2 of 20

2.09

1.04

0.0108

GO:0005634

Nucleus

10 of 2448

0.7

0.61

0.00015

GO:0031981

Nuclear lumen

4 of 552

0.95

0.49

0.0490

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:8024

mRNA Splicing

9 of 62

2.25

6.79

1.98e-16

CL:8134

Kinase inhibitor activity, and Programmed cell death

5 of 5

3.09

6.03

7.59e-12

CL:7874

Spliceosomal complex, and Processing of Capped Intron-Containing Pre-mRNA

10 of 178

1.84

4.84

1.57e-15

CL:8091

Mixed, incl. Cyclophilin-type peptidyl-prolyl cis-trans isomerase, cyclophilin A-like, and PWI domain

4 of 10

2.69

3.88

5.13e-08

CL:8094

Cyclophilin-type peptidyl-prolyl cis-trans isomerase, cyclophilin A-like, and Initiation factor eIF-4 gamma, MA3

3 of 5

2.86

2.92

4.34e-06

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03040

Spliceosome

4 of 203

1.38

1.08

0.0024

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-72163

mRNA Splicing - Major Pathway

11 of 142

1.98

6.3

2.71e-19

MAP-72172

mRNA Splicing

11 of 155

1.94

6.06

3.42e-19

MAP-72203

Processing of Capped Intron-Containing Pre-mRNA

11 of 254

1.72

4.53

4.45e-17

MAP-8953854

Metabolism of RNA

11 of 648

1.32

2.31

8.52e-13

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005681

Spliceosomal complex

5 of 92

1.82

2.28

7.45e-06

GOCC:0071014

post-mRNA release spliceosomal complex

2 of 13

2.27

1.08

0.0100

GOCC:0005634

Nucleus

7 of 1396

0.79

0.54

0.0095

GOCC:0043231

Intracellular membrane-bounded organelle

9 of 2891

0.58

0.41

0.0095

GOCC:0043229

Intracellular organelle

10 of 3996

0.48

0.36

0.0095

(more ...)

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