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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sucC1SucC1; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (385 aa)    
Predicted Functional Partners:
sucD2
SucD2; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
 0.999
sdhB
SdhB; Succinate dehydrogenase/fumarate reductase, iron-sulfur containing subunit SdhB.
 
 0.996
sdhC
SdhC; Succinate dehydrogenase/fumarate reductase, cytochrome b containing subunit SdhC.
  
 
 0.994
pdhC
PdhC; Dihydrolipoamide acetyltransferase PdhC (pyruvate dehydrogenase complex, E2 component).
 
 0.988
sdhA
SdhA; Succinate dehydrogenase/fumarate reductase, flavoprotein containing subunit SdhA.
 0.987
sbm
Sbm; Homodimeric methylmalonyl-CoA mutase Sbm (MCM-alpha).
  
 
 0.984
gltA4
GltA4; Citrate (si)-synthase GltA3; Belongs to the citrate synthase family.
  
 
 0.941
gltA1
GltA1; Citrate (si)-synthase GltA1; Belongs to the citrate synthase family.
  
 
 0.935
gltA3
GltA3; Citrate (si)-synthase GltA2; Belongs to the citrate synthase family.
  
 
 0.935
porA4
PorA4; Pyruvate:ferredoxin oxidoreductase, subunit PorA4.
  
 
 0.931
Your Current Organism:
Desulfobacterium autotrophicum
NCBI taxonomy Id: 177437
Other names: D. autotrophicum HRM2, Desulfobacterium autotrophicum HRM2, Desulfobacterium autotrophicum str. HRM2, Desulfobacterium autotrophicum strain HRM2
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