STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ACN16344.1Heat shock protein (HSP20 family protein); Belongs to the small heat shock protein (HSP20) family. (148 aa)    
Predicted Functional Partners:
ACN16345.1
Heat shock protein, 18.5 kDa class I (HSP 18.5, HSP20-like chaperone); Belongs to the small heat shock protein (HSP20) family.
 
   
0.788
ACN17989.1
Small heat shock protein (Hsp20 family protein); Belongs to the small heat shock protein (HSP20) family.
  
     0.775
clpB
ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family.
 
 
 0.705
clpA
ClpA; ATP-dependent Clp protease, ATP-binding subunit ClpA; Belongs to the ClpA/ClpB family.
  
 
 0.650
htpG
HtpG; Molecular chaperone. Has ATPase activity.
  
 
 0.580
ACN14004.1
Conserved hypothetical protein; Belongs to the AAA ATPase family.
  
  
 0.566
grpE
GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interacti [...]
  
  
 0.494
hslV
HslV; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.
   
  
 0.467
dnaK1
DnaK1; Acts as a chaperone; Belongs to the heat shock protein 70 family.
  
 
 0.449
dnaK3
DnaK3; Chaperone heat-shock protein DnaK.
  
 
 0.449
Your Current Organism:
Desulfobacterium autotrophicum
NCBI taxonomy Id: 177437
Other names: D. autotrophicum HRM2, Desulfobacterium autotrophicum HRM2, Desulfobacterium autotrophicum str. HRM2, Desulfobacterium autotrophicum strain HRM2
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.