| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| glyA | pabB | HRM2_31300 | HRM2_08090 | GlyA; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | PabB; Para-aminobenzoate synthase, component I. | 0.551 |
| glyA | serB | HRM2_31300 | HRM2_42260 | GlyA; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | SerB; Phosphoserine phosphatase SerB (PSP). | 0.954 |
| glyA | trpA | HRM2_31300 | HRM2_33430 | GlyA; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | TrpA; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.941 |
| glyA | trpB | HRM2_31300 | HRM2_33440 | GlyA; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | TrpB; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.934 |
| glyA | trpC | HRM2_31300 | HRM2_17680 | GlyA; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | TrpC; Tryptophan biosynthesis protein TrpC (anthranilate synthase complex). | 0.462 |
| pabA | pabB | HRM2_08100 | HRM2_08090 | PabA; Para-aminobenzoate synthase, component II. | PabB; Para-aminobenzoate synthase, component I. | 0.999 |
| pabA | trpA | HRM2_08100 | HRM2_33430 | PabA; Para-aminobenzoate synthase, component II. | TrpA; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.963 |
| pabA | trpB | HRM2_08100 | HRM2_33440 | PabA; Para-aminobenzoate synthase, component II. | TrpB; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.955 |
| pabA | trpC | HRM2_08100 | HRM2_17680 | PabA; Para-aminobenzoate synthase, component II. | TrpC; Tryptophan biosynthesis protein TrpC (anthranilate synthase complex). | 0.999 |
| pabA | trpD1 | HRM2_08100 | HRM2_16000 | PabA; Para-aminobenzoate synthase, component II. | TrpD1; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). | 0.999 |
| pabA | trpD2 | HRM2_08100 | HRM2_17690 | PabA; Para-aminobenzoate synthase, component II. | TrpD2; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). | 0.999 |
| pabA | trpE | HRM2_08100 | HRM2_17710 | PabA; Para-aminobenzoate synthase, component II. | TrpE; Anthranilate synthase component I. | 0.999 |
| pabA | trpG | HRM2_08100 | HRM2_17700 | PabA; Para-aminobenzoate synthase, component II. | TrpG; Anthranilate/para-aminobenzoate synthases component II. | 0.906 |
| pabB | glyA | HRM2_08090 | HRM2_31300 | PabB; Para-aminobenzoate synthase, component I. | GlyA; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.551 |
| pabB | pabA | HRM2_08090 | HRM2_08100 | PabB; Para-aminobenzoate synthase, component I. | PabA; Para-aminobenzoate synthase, component II. | 0.999 |
| pabB | serB | HRM2_08090 | HRM2_42260 | PabB; Para-aminobenzoate synthase, component I. | SerB; Phosphoserine phosphatase SerB (PSP). | 0.522 |
| pabB | trpA | HRM2_08090 | HRM2_33430 | PabB; Para-aminobenzoate synthase, component I. | TrpA; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.980 |
| pabB | trpB | HRM2_08090 | HRM2_33440 | PabB; Para-aminobenzoate synthase, component I. | TrpB; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.978 |
| pabB | trpC | HRM2_08090 | HRM2_17680 | PabB; Para-aminobenzoate synthase, component I. | TrpC; Tryptophan biosynthesis protein TrpC (anthranilate synthase complex). | 0.999 |
| pabB | trpD1 | HRM2_08090 | HRM2_16000 | PabB; Para-aminobenzoate synthase, component I. | TrpD1; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). | 0.994 |