STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hemCHemC; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (325 aa)    
Predicted Functional Partners:
hemD
HemD; Porphyrin biosynthesis protein HemD [includes: uroporphyrin-III C-methyltransferase; uroporphyrinogen-III synthase].
 0.999
hemB
HemB; Delta-aminolevulinic acid dehydratase HemB (porphobilinogensynthase); Belongs to the ALAD family.
 
 0.997
hemA
HemA; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
  
 0.996
hemL
HemL; Glutamate-1-semialdehyde 2,1-aminomutase HemL.
  
 0.965
cysG
CysG; Siroheme synthase (uroporphyrin-III C-methyltransferase; precorrin-2 dehydrogenase; sirohydrochlorin ferrochelatase).
  
 0.953
moaA2
MoaA2; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate.
       0.796
ACN16663.1
Putative reponse regulator (CheY and GGDEF domain family protein).
       0.709
xseB
XseB; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family.
   
    0.658
hemE
HemE; Uroporphyrinogen decarboxylase HemE (URO-D); Belongs to the uroporphyrinogen decarboxylase family.
  
 
 0.642
uroD
UroD; Uroporphyrinogen decarboxylase UroD; Belongs to the uroporphyrinogen decarboxylase family.
  
 
 0.642
Your Current Organism:
Desulfobacterium autotrophicum
NCBI taxonomy Id: 177437
Other names: D. autotrophicum HRM2, Desulfobacterium autotrophicum HRM2, Desulfobacterium autotrophicum str. HRM2, Desulfobacterium autotrophicum strain HRM2
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