node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
alkA | birA | HRM2_35040 | HRM2_26920 | AlkA; 3-methyladenine DNA glycosylase AlkA (3-methyladenine-DNA glycosidase). | BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | 0.606 |
alkA | dnaN | HRM2_35040 | HRM2_00010 | AlkA; 3-methyladenine DNA glycosylase AlkA (3-methyladenine-DNA glycosidase). | DnaN; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for [...] | 0.588 |
alkA | exoA | HRM2_35040 | HRM2_40990 | AlkA; 3-methyladenine DNA glycosylase AlkA (3-methyladenine-DNA glycosidase). | ExoA; Exodeoxyribonuclease III (ExoA). | 0.969 |
alkA | ligA2 | HRM2_35040 | HRM2_32340 | AlkA; 3-methyladenine DNA glycosylase AlkA (3-methyladenine-DNA glycosidase). | LigA2; DNA ligase LigA (Polydeoxyribonucleotide synthase). | 0.409 |
alkA | mutY | HRM2_35040 | HRM2_46670 | AlkA; 3-methyladenine DNA glycosylase AlkA (3-methyladenine-DNA glycosidase). | MutY; A/G-specific adenine glycosylase MutY. | 0.424 |
alkA | nfo | HRM2_35040 | HRM2_34030 | AlkA; 3-methyladenine DNA glycosylase AlkA (3-methyladenine-DNA glycosidase). | Nfo; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate. | 0.576 |
alkA | nth | HRM2_35040 | HRM2_46220 | AlkA; 3-methyladenine DNA glycosylase AlkA (3-methyladenine-DNA glycosidase). | Putative endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. | 0.441 |
alkA | nthA | HRM2_35040 | HRM2_00210 | AlkA; 3-methyladenine DNA glycosylase AlkA (3-methyladenine-DNA glycosidase). | NthA; DNA-binding endonuclease III NthA (helix-hairpin-helix DNA-binding protein). | 0.441 |
alkA | polA | HRM2_35040 | HRM2_12370 | AlkA; 3-methyladenine DNA glycosylase AlkA (3-methyladenine-DNA glycosidase). | PolA; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.694 |
alkA | polB | HRM2_35040 | HRM2_14420 | AlkA; 3-methyladenine DNA glycosylase AlkA (3-methyladenine-DNA glycosidase). | PolB; DNA polymerase II PolB. | 0.521 |
birA | alkA | HRM2_26920 | HRM2_35040 | BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | AlkA; 3-methyladenine DNA glycosylase AlkA (3-methyladenine-DNA glycosidase). | 0.606 |
birA | exoA | HRM2_26920 | HRM2_40990 | BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | ExoA; Exodeoxyribonuclease III (ExoA). | 0.893 |
birA | mutY | HRM2_26920 | HRM2_46670 | BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | MutY; A/G-specific adenine glycosylase MutY. | 0.537 |
dnaN | alkA | HRM2_00010 | HRM2_35040 | DnaN; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for [...] | AlkA; 3-methyladenine DNA glycosylase AlkA (3-methyladenine-DNA glycosidase). | 0.588 |
dnaN | exoA | HRM2_00010 | HRM2_40990 | DnaN; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for [...] | ExoA; Exodeoxyribonuclease III (ExoA). | 0.979 |
dnaN | ligA2 | HRM2_00010 | HRM2_32340 | DnaN; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for [...] | LigA2; DNA ligase LigA (Polydeoxyribonucleotide synthase). | 0.996 |
dnaN | mutY | HRM2_00010 | HRM2_46670 | DnaN; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for [...] | MutY; A/G-specific adenine glycosylase MutY. | 0.641 |
dnaN | polA | HRM2_00010 | HRM2_12370 | DnaN; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for [...] | PolA; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.999 |
dnaN | polB | HRM2_00010 | HRM2_14420 | DnaN; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for [...] | PolB; DNA polymerase II PolB. | 0.999 |
exoA | alkA | HRM2_40990 | HRM2_35040 | ExoA; Exodeoxyribonuclease III (ExoA). | AlkA; 3-methyladenine DNA glycosylase AlkA (3-methyladenine-DNA glycosidase). | 0.969 |