mttB9 protein (Desulfobacterium autotrophicum)

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second shell of interactors

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filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Coexpression

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[Homology]

Score

mttB9

MttB9; Trimethylamine methyltransferase MttB (TMA methyltransferase). (489 aa)

Predicted Functional Partners:

ACN13246.1

0.714

ACN16953.1

0.714

ACN14529.1

0.698

mtbC1

0.657

mtbC2

0.657

fdx7

0.656

ACN15693.1

0.629

ACN14699.1

0.610

ACN17743.1

0.596

fdx8

0.585

Your Current Organism:

Desulfobacterium autotrophicum

NCBI taxonomy Id: 177437
Other names: D. autotrophicum HRM2, Desulfobacterium autotrophicum HRM2, Desulfobacterium autotrophicum str. HRM2, Desulfobacterium autotrophicum strain HRM2

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACN13246.1	ACN16953.1	HRM2_01230	HRM2_38950	Putative methionine synthase I metH2.	Ferredoxin (4Fe-4S iron-sulfur cluster binding protein).	0.743
ACN13246.1	ACN17743.1	HRM2_01230	HRM2_46870	Putative methionine synthase I metH2.	Metal-binding protein.	0.731
ACN13246.1	fdx7	HRM2_01230	HRM2_30720	Putative methionine synthase I metH2.	Fdx7; 4Fe-4S ferredoxin, iron-sulfur binding family protein Fdx7.	0.749
ACN13246.1	fdx8	HRM2_01230	HRM2_30730	Putative methionine synthase I metH2.	Fdx8; 4Fe-4S ferredoxin, iron-sulfur binding family protein Fdx8.	0.730
ACN13246.1	mttB9	HRM2_01230	HRM2_44190	Putative methionine synthase I metH2.	MttB9; Trimethylamine methyltransferase MttB (TMA methyltransferase).	0.714
ACN14529.1	ACN16953.1	HRM2_14200	HRM2_38950	Putative B12-dependent methionine synthase family protein.	Ferredoxin (4Fe-4S iron-sulfur cluster binding protein).	0.440
ACN14529.1	mtbC1	HRM2_14200	HRM2_07350	Putative B12-dependent methionine synthase family protein.	MtbC1; Methionine synthase MtbC (5-methyltetrahydrofolate-- homocysteine methyltransferase) (Methionine synthase, vitamin-B12 dependent isozyme) (MS).	0.923
ACN14529.1	mtbC2	HRM2_14200	HRM2_34310	Putative B12-dependent methionine synthase family protein.	MtbC2; Dimethylamine corrinoid protein MtbC.	0.923
ACN14529.1	mttB9	HRM2_14200	HRM2_44190	Putative B12-dependent methionine synthase family protein.	MttB9; Trimethylamine methyltransferase MttB (TMA methyltransferase).	0.698
ACN14699.1	ACN15693.1	HRM2_15900	HRM2_25990	Hypothetical protein.	Putative hydantoinase/oxoprolinase fusion protein (hydantoin converting enzyme).	0.543
ACN14699.1	ACN16953.1	HRM2_15900	HRM2_38950	Hypothetical protein.	Ferredoxin (4Fe-4S iron-sulfur cluster binding protein).	0.740
ACN14699.1	ACN17743.1	HRM2_15900	HRM2_46870	Hypothetical protein.	Metal-binding protein.	0.687
ACN14699.1	fdx7	HRM2_15900	HRM2_30720	Hypothetical protein.	Fdx7; 4Fe-4S ferredoxin, iron-sulfur binding family protein Fdx7.	0.732
ACN14699.1	fdx8	HRM2_15900	HRM2_30730	Hypothetical protein.	Fdx8; 4Fe-4S ferredoxin, iron-sulfur binding family protein Fdx8.	0.703
ACN14699.1	mttB9	HRM2_15900	HRM2_44190	Hypothetical protein.	MttB9; Trimethylamine methyltransferase MttB (TMA methyltransferase).	0.610
ACN15693.1	ACN14699.1	HRM2_25990	HRM2_15900	Putative hydantoinase/oxoprolinase fusion protein (hydantoin converting enzyme).	Hypothetical protein.	0.543
ACN15693.1	mttB9	HRM2_25990	HRM2_44190	Putative hydantoinase/oxoprolinase fusion protein (hydantoin converting enzyme).	MttB9; Trimethylamine methyltransferase MttB (TMA methyltransferase).	0.629
ACN16953.1	ACN13246.1	HRM2_38950	HRM2_01230	Ferredoxin (4Fe-4S iron-sulfur cluster binding protein).	Putative methionine synthase I metH2.	0.743
ACN16953.1	ACN14529.1	HRM2_38950	HRM2_14200	Ferredoxin (4Fe-4S iron-sulfur cluster binding protein).	Putative B12-dependent methionine synthase family protein.	0.440
ACN16953.1	ACN14699.1	HRM2_38950	HRM2_15900	Ferredoxin (4Fe-4S iron-sulfur cluster binding protein).	Hypothetical protein.	0.740

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

54

average node degree:

9.82

avg. local clustering coefficient:

0.982

expected number of edges:

17

PPI enrichment p-value:

3.77e-13

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0019413

Acetate biosynthetic process

7 of 16

2.91

7.87

1.12e-15

GO:0046187

Acetaldehyde catabolic process

7 of 20

2.82

7.64

2.02e-15

GO:0045991

Carbon catabolite activation of transcription

7 of 20

2.82

7.64

2.02e-15

GO:0006068

Ethanol catabolic process

7 of 20

2.82

7.64

2.02e-15

GO:0006567

Threonine catabolic process

7 of 36

2.56

6.88

1.33e-14

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0043878

glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity

7 of 16

2.91

8.01

5.80e-16

GO:0004029

Aldehyde dehydrogenase (NAD+) activity

7 of 20

2.82

7.78

1.05e-15

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005576

Extracellular region

7 of 876

1.17

1.21

7.37e-05

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:24255

Mixed, incl. Acetate metabolic process, and Valine catabolic process

7 of 32

2.61

6.67

5.98e-14

CL:24257

Acetate metabolic process, and Valine catabolic process

5 of 18

2.72

5.04

2.64e-10

CL:24259

acetate-CoA ligase activity, and Valine catabolic process

4 of 13

2.76

3.92

4.80e-08

CL:24261

Valine catabolic process, and acetate-CoA ligase activity

2 of 7

2.73

1.33

0.0038

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00340

Histidine metabolism

7 of 68

2.28

5.74

3.34e-13

map00410

beta-Alanine metabolism

7 of 95

2.14

5.25

7.72e-13

map00053

Ascorbate and aldarate metabolism

7 of 95

2.14

5.25

7.72e-13

map00770

Pantothenate and CoA biosynthesis

7 of 102

2.11

5.15

8.30e-13

map00280

Valine, leucine and isoleucine degradation

8 of 176

1.93

4.67

4.51e-13

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-380615

Serotonin clearance from the synaptic cleft

7 of 19

2.84

7.89

6.93e-16

MAP-380612

Metabolism of serotonin

7 of 19

2.84

7.89

6.93e-16

MAP-445355

Smooth Muscle Contraction

7 of 24

2.74

7.7

9.22e-16

MAP-70350

Fructose catabolism

7 of 29

2.65

7.39

2.19e-15

MAP-71384

Ethanol oxidation

7 of 33

2.6

7.18

3.92e-15

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005576

Extracellular region

7 of 767

1.23

1.34

3.68e-05

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0560

Oxidoreductase

5 of 325

1.46

1.52

0.00011

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00171

Aldehyde dehydrogenase family

7 of 50

2.42

5.88

7.27e-13

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR016162

Aldehyde dehydrogenase, N-terminal

7 of 51

2.41

5.67

2.10e-12

IPR015590

Aldehyde dehydrogenase domain

7 of 53

2.39

5.64

2.10e-12

IPR016161

Aldehyde/histidinol dehydrogenase

7 of 60

2.34

5.54

2.10e-12

IPR029510

Aldehyde dehydrogenase, glutamic acid active site

5 of 32

2.47

4.08

1.07e-08

IPR016163

Aldehyde dehydrogenase, C-terminal

5 of 44

2.33

3.72

3.74e-08

(more ...)

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