STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nthPutative endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (212 aa)    
Predicted Functional Partners:
exoA
ExoA; Exodeoxyribonuclease III (ExoA).
 0.973
nthA
NthA; DNA-binding endonuclease III NthA (helix-hairpin-helix DNA-binding protein).
  
  
 
0.918
rnfE2
RnfE2; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
 
  
 0.791
rnfE1
RnfE1; Electron transport complex protein Rnf; Belongs to the NqrDE/RnfAE family.
 
  
 0.696
rnfG2
RnfG2; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the RnfG family.
  
  
 0.660
polA
PolA; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 
 0.634
nfo
Nfo; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.
  
 
 0.584
ACN14901.1
ATP-utilizing protein of the PP-loop superfamily.
 
    0.529
ACN17679.1
Hypothetical protein.
       0.515
ispB
IspB; Octaprenyl-diphosphate synthase IspB; Belongs to the FPP/GGPP synthase family.
 
    0.507
Your Current Organism:
Desulfobacterium autotrophicum
NCBI taxonomy Id: 177437
Other names: D. autotrophicum HRM2, Desulfobacterium autotrophicum HRM2, Desulfobacterium autotrophicum str. HRM2, Desulfobacterium autotrophicum strain HRM2
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