| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACN17767.1 | dnaN | HRM2_47180 | HRM2_00010 | Putative ATP-dependent DNA helicase. | DnaN; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for [...] | 0.940 |
| ACN17767.1 | recB | HRM2_47180 | HRM2_26490 | Putative ATP-dependent DNA helicase. | RecB; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any li [...] | 0.552 |
| ACN17767.1 | recC | HRM2_47180 | HRM2_26500 | Putative ATP-dependent DNA helicase. | RecC; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any li [...] | 0.508 |
| ACN17767.1 | recD1 | HRM2_47180 | HRM2_23450 | Putative ATP-dependent DNA helicase. | RecD1; DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity; Belongs to the RecD family. RecD-like subfamily. | 0.905 |
| ACN17767.1 | recD2 | HRM2_47180 | HRM2_26480 | Putative ATP-dependent DNA helicase. | RecD2; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any l [...] | 0.905 |
| ACN17767.1 | recD3 | HRM2_47180 | HRM2_49370 | Putative ATP-dependent DNA helicase. | RecD3; DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity; Belongs to the RecD family. RecD-like subfamily. | 0.905 |
| ACN17989.1 | gmhB | HRM2_49410 | HRM2_49380 | Small heat shock protein (Hsp20 family protein); Belongs to the small heat shock protein (HSP20) family. | GmhB; D,D-heptose 1,7-bisphosphate phosphatase GmhB. | 0.752 |
| ACN17989.1 | lonA | HRM2_49410 | HRM2_49400 | Small heat shock protein (Hsp20 family protein); Belongs to the small heat shock protein (HSP20) family. | LonA; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. | 0.811 |
| ACN17989.1 | recD3 | HRM2_49410 | HRM2_49370 | Small heat shock protein (Hsp20 family protein); Belongs to the small heat shock protein (HSP20) family. | RecD3; DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity; Belongs to the RecD family. RecD-like subfamily. | 0.745 |
| ACN17989.1 | rlpA-2 | HRM2_49410 | HRM2_49390 | Small heat shock protein (Hsp20 family protein); Belongs to the small heat shock protein (HSP20) family. | RlpA-like lipoprotein precursor; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides. | 0.729 |
| dnaN | ACN17767.1 | HRM2_00010 | HRM2_47180 | DnaN; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for [...] | Putative ATP-dependent DNA helicase. | 0.940 |
| dnaN | recD1 | HRM2_00010 | HRM2_23450 | DnaN; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for [...] | RecD1; DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity; Belongs to the RecD family. RecD-like subfamily. | 0.760 |
| dnaN | recD2 | HRM2_00010 | HRM2_26480 | DnaN; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for [...] | RecD2; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any l [...] | 0.760 |
| dnaN | recD3 | HRM2_00010 | HRM2_49370 | DnaN; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for [...] | RecD3; DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity; Belongs to the RecD family. RecD-like subfamily. | 0.760 |
| gmhB | ACN17989.1 | HRM2_49380 | HRM2_49410 | GmhB; D,D-heptose 1,7-bisphosphate phosphatase GmhB. | Small heat shock protein (Hsp20 family protein); Belongs to the small heat shock protein (HSP20) family. | 0.752 |
| gmhB | lonA | HRM2_49380 | HRM2_49400 | GmhB; D,D-heptose 1,7-bisphosphate phosphatase GmhB. | LonA; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. | 0.818 |
| gmhB | recD3 | HRM2_49380 | HRM2_49370 | GmhB; D,D-heptose 1,7-bisphosphate phosphatase GmhB. | RecD3; DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity; Belongs to the RecD family. RecD-like subfamily. | 0.832 |
| gmhB | rlpA-2 | HRM2_49380 | HRM2_49390 | GmhB; D,D-heptose 1,7-bisphosphate phosphatase GmhB. | RlpA-like lipoprotein precursor; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides. | 0.805 |
| lonA | ACN17989.1 | HRM2_49400 | HRM2_49410 | LonA; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. | Small heat shock protein (Hsp20 family protein); Belongs to the small heat shock protein (HSP20) family. | 0.811 |
| lonA | gmhB | HRM2_49400 | HRM2_49380 | LonA; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. | GmhB; D,D-heptose 1,7-bisphosphate phosphatase GmhB. | 0.818 |
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