STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KUO39909.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (438 aa)    
Predicted Functional Partners:
KUO39908.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 0.999
KUO42521.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 0.983
fen
Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...]
 
 0.968
KUO39912.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.
  
 0.904
KUO40299.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 0.855
topA
Hypothetical protein; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA sup [...]
 
 0.835
KUO39834.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.813
KUO40130.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.807
rfcL
Hypothetical protein; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcL subfamily.
  
 0.766
KUO42437.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
 0.757
Your Current Organism:
Hadesarchaea archaeon
NCBI taxonomy Id: 1776334
Other names: H. archaeon YNP_45, Hadesarchaea archaeon YNP_45
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.