STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KUO39656.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (189 aa)    
Predicted Functional Partners:
guaA
Hypothetical protein; Catalyzes the synthesis of GMP from XMP.
    
 0.877
KUO39397.1
Non-canonical purine NTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
    
  0.779
KUO39300.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
 0.749
KUO39655.1
XRE family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
     0.746
purA
Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
    
 0.732
KUO40931.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.721
trpF
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TrpF family.
    
 0.717
ahcY
Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
    
 0.714
KUO39343.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
  0.699
KUO39685.1
S-adenosylmethionine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.610
Your Current Organism:
Hadesarchaea archaeon
NCBI taxonomy Id: 1776334
Other names: H. archaeon YNP_45, Hadesarchaea archaeon YNP_45
Server load: low (36%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.