WN55_03845 protein (Dufourea novaeangliae) - STRING interaction network

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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Score

WN55_03845

Retinol dehydrogenase 12. (326 aa)

Predicted Functional Partners:

WN55_08668

0.785

WN55_08553

0.780

WN55_11426

0.780

WN55_02335

0.716

WN55_01024

0.712

WN55_00639

0.709

WN55_06517

0.702

WN55_00660

0.701

WN55_05734

0.701

WN55_00111

0.698

Your Current Organism:

Dufourea novaeangliae

NCBI taxonomy Id: 178035
Other names: D. novaeangliae, Dufourea nova-angliae

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
WN55_00111	WN55_03845	A0A154NWH1	A0A154NYW2	Receptor protein-tyrosine kinase.	Retinol dehydrogenase 12.	0.698
WN55_00111	WN55_08668	A0A154NWH1	A0A154NZN6	Receptor protein-tyrosine kinase.	Dehydrogenase/reductase SDR family member 4.	0.608
WN55_00639	WN55_01024	A0A154NZP9	A0A154PDV3	Cytochrome b5 reductase 4.	Adrenodoxin-like protein, mitochondrial.	0.819
WN55_00639	WN55_03845	A0A154NZP9	A0A154NYW2	Cytochrome b5 reductase 4.	Retinol dehydrogenase 12.	0.709
WN55_00639	WN55_06517	A0A154NZP9	A0A154PQH9	Cytochrome b5 reductase 4.	Adrenodoxin, mitochondrial.	0.819
WN55_00639	WN55_08668	A0A154NZP9	A0A154NZN6	Cytochrome b5 reductase 4.	Dehydrogenase/reductase SDR family member 4.	0.709
WN55_00639	WN55_11426	A0A154NZP9	A0A154PAU4	Cytochrome b5 reductase 4.	S-(hydroxymethyl)glutathione dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.	0.666
WN55_00660	WN55_02335	A0A154NY31	A0A154PIC5	3-oxoacyl-[acyl-carrier-protein] synthase; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.	Armadillo repeat-containing protein 7.	0.655
WN55_00660	WN55_03845	A0A154NY31	A0A154NYW2	3-oxoacyl-[acyl-carrier-protein] synthase; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.	Retinol dehydrogenase 12.	0.701
WN55_00660	WN55_08668	A0A154NY31	A0A154NZN6	3-oxoacyl-[acyl-carrier-protein] synthase; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.	Dehydrogenase/reductase SDR family member 4.	0.889
WN55_01024	WN55_00639	A0A154PDV3	A0A154NZP9	Adrenodoxin-like protein, mitochondrial.	Cytochrome b5 reductase 4.	0.819
WN55_01024	WN55_02335	A0A154PDV3	A0A154PIC5	Adrenodoxin-like protein, mitochondrial.	Armadillo repeat-containing protein 7.	0.442
WN55_01024	WN55_03845	A0A154PDV3	A0A154NYW2	Adrenodoxin-like protein, mitochondrial.	Retinol dehydrogenase 12.	0.712
WN55_01024	WN55_06517	A0A154PDV3	A0A154PQH9	Adrenodoxin-like protein, mitochondrial.	Adrenodoxin, mitochondrial.	0.549
WN55_01024	WN55_08668	A0A154PDV3	A0A154NZN6	Adrenodoxin-like protein, mitochondrial.	Dehydrogenase/reductase SDR family member 4.	0.705
WN55_01024	WN55_11426	A0A154PDV3	A0A154PAU4	Adrenodoxin-like protein, mitochondrial.	S-(hydroxymethyl)glutathione dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.	0.716
WN55_02335	WN55_00660	A0A154PIC5	A0A154NY31	Armadillo repeat-containing protein 7.	3-oxoacyl-[acyl-carrier-protein] synthase; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.	0.655
WN55_02335	WN55_01024	A0A154PIC5	A0A154PDV3	Armadillo repeat-containing protein 7.	Adrenodoxin-like protein, mitochondrial.	0.442
WN55_02335	WN55_03845	A0A154PIC5	A0A154NYW2	Armadillo repeat-containing protein 7.	Retinol dehydrogenase 12.	0.716
WN55_02335	WN55_06517	A0A154PIC5	A0A154PQH9	Armadillo repeat-containing protein 7.	Adrenodoxin, mitochondrial.	0.442

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Network Stats

number of nodes:

11

number of edges:

46

average node degree:

8.36

avg. local clustering coefficient:

0.917

expected number of edges:

14

PPI enrichment p-value:

2.83e-11

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006631

Fatty acid metabolic process

4 of 24

1.61

1.17

0.0030

GO:0019605

Butyrate metabolic process

2 of 2

2.39

0.84

0.0286

GO:0017000

Antibiotic biosynthetic process

3 of 17

1.64

0.77

0.0286

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031177

Phosphopantetheine binding

3 of 3

2.39

1.74

0.00056

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1312

Mixed, incl. AMP-binding enzyme, and Butyrate metabolic process

7 of 10

2.24

5.06

1.07e-11

CL:1286

Mixed, incl. Fatty acid metabolism, and KR domain

8 of 23

1.93

4.31

1.07e-11

CL:1314

AMP-binding enzyme, and Polyketide synthase, ketoreductase domain

3 of 5

2.17

1.84

0.00028

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005777

Peroxisome

4 of 6

2.21

2.6

7.15e-06

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0596

Phosphopantetheine

2 of 4

2.09

0.74

0.0420

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00550

Phosphopantetheine attachment site

5 of 8

2.19

3.27

2.05e-07

PF16197

Ketoacyl-synthetase C-terminal extension

3 of 3

2.39

1.96

0.00021

PF02801

Beta-ketoacyl synthase, C-terminal domain

3 of 4

2.27

1.9

0.00024

PF00109

Beta-ketoacyl synthase, N-terminal domain

3 of 4

2.27

1.9

0.00024

PF00501

AMP-binding enzyme

2 of 4

2.09

0.92

0.0190

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036736

ACP-like superfamily

5 of 8

2.19

3.09

5.38e-07

IPR009081

Phosphopantetheine binding ACP domain

5 of 8

2.19

3.09

5.38e-07

IPR032821

Polyketide synthase, C-terminal extension

3 of 3

2.39

1.83

0.00037

IPR020841

Polyketide synthase, beta-ketoacyl synthase domain

3 of 4

2.27

1.75

0.00048

IPR018201

Beta-ketoacyl synthase, active site

3 of 4

2.27

1.75

0.00048

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00822

This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group.

2 of 2

2.39

1.09

0.0097

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