WN55_09736 protein (Dufourea novaeangliae) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

WN55_09736

Transcriptional repressor scratch 1. (549 aa)

Predicted Functional Partners:

WN55_04597

0.489

WN55_07586

0.486

WN55_03241

0.486

WN55_05117

0.474

WN55_08525

0.473

WN55_07838

0.453

WN55_09094

0.443

WN55_08373

0.442

WN55_10619

0.425

WN55_00255

0.425

Your Current Organism:

Dufourea novaeangliae

NCBI taxonomy Id: 178035
Other names: D. novaeangliae, Dufourea nova-angliae

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... functional annotations:

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
WN55_00255	WN55_03241	A0A154PCN1	A0A154PLQ9	Lysine-specific histone demethylase 1A.	C-terminal-binding protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.848
WN55_00255	WN55_07586	A0A154PCN1	A0A154P466	Lysine-specific histone demethylase 1A.	REST corepressor.	0.979
WN55_00255	WN55_09736	A0A154PCN1	A0A154NZ76	Lysine-specific histone demethylase 1A.	Transcriptional repressor scratch 1.	0.425
WN55_03241	WN55_00255	A0A154PLQ9	A0A154PCN1	C-terminal-binding protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Lysine-specific histone demethylase 1A.	0.848
WN55_03241	WN55_07586	A0A154PLQ9	A0A154P466	C-terminal-binding protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	REST corepressor.	0.742
WN55_03241	WN55_07838	A0A154PLQ9	A0A154PUW0	C-terminal-binding protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	F-box/WD repeat-containing protein 1A.	0.589
WN55_03241	WN55_09736	A0A154PLQ9	A0A154NZ76	C-terminal-binding protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Transcriptional repressor scratch 1.	0.486
WN55_04597	WN55_08373	A0A154P1C6	A0A154P6X7	T-related protein.	T-box transcription factor TBX2.	0.614
WN55_04597	WN55_09736	A0A154P1C6	A0A154NZ76	T-related protein.	Transcriptional repressor scratch 1.	0.489
WN55_05117	WN55_07838	A0A154PNV6	A0A154PUW0	Protein kinase shaggy.	F-box/WD repeat-containing protein 1A.	0.948
WN55_05117	WN55_09736	A0A154PNV6	A0A154NZ76	Protein kinase shaggy.	Transcriptional repressor scratch 1.	0.474
WN55_07586	WN55_00255	A0A154P466	A0A154PCN1	REST corepressor.	Lysine-specific histone demethylase 1A.	0.979
WN55_07586	WN55_03241	A0A154P466	A0A154PLQ9	REST corepressor.	C-terminal-binding protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.742
WN55_07586	WN55_09736	A0A154P466	A0A154NZ76	REST corepressor.	Transcriptional repressor scratch 1.	0.486
WN55_07838	WN55_03241	A0A154PUW0	A0A154PLQ9	F-box/WD repeat-containing protein 1A.	C-terminal-binding protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.589
WN55_07838	WN55_05117	A0A154PUW0	A0A154PNV6	F-box/WD repeat-containing protein 1A.	Protein kinase shaggy.	0.948
WN55_07838	WN55_09736	A0A154PUW0	A0A154NZ76	F-box/WD repeat-containing protein 1A.	Transcriptional repressor scratch 1.	0.453
WN55_08373	WN55_04597	A0A154P6X7	A0A154P1C6	T-box transcription factor TBX2.	T-related protein.	0.614
WN55_08373	WN55_09736	A0A154P6X7	A0A154NZ76	T-box transcription factor TBX2.	Transcriptional repressor scratch 1.	0.442
WN55_08525	WN55_09736	A0A154P5L2	A0A154NZ76	Importin subunit beta-1.	Transcriptional repressor scratch 1.	0.473

page 1 of 2

Network Stats

number of nodes:

2

number of edges:

1

average node degree:

1

avg. local clustering coefficient:

1

expected number of edges:

1

PPI enrichment p-value:

0.5

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000724

Double-strand break repair via homologous recombination

3 of 4

2.43

1.93

0.00054

GO:0006281

DNA repair

4 of 50

1.46

1.23

0.0020

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003690

Double-stranded DNA binding

3 of 14

1.89

1.25

0.0057

GO:0003678

DNA helicase activity

3 of 14

1.89

1.25

0.0057

GO:0004527

Exonuclease activity

3 of 20

1.73

1.2

0.0057

GO:0016887

ATP hydrolysis activity

3 of 41

1.42

0.86

0.0179

GO:0008408

3-5 exonuclease activity

2 of 9

1.9

0.86

0.0319

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0033202

DNA helicase complex

3 of 8

2.13

2.0

0.00027

GO:1902494

Catalytic complex

4 of 68

1.33

1.21

0.00092

GO:0032991

Protein-containing complex

5 of 170

1.03

0.88

0.0011

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1230

PD-(D/E)XK nuclease superfamily, and CBS domain

4 of 6

2.38

3.11

3.40e-06

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0033202

DNA helicase complex

3 of 13

1.92

1.48

0.0020

GOCC:0044815

DNA packaging complex

3 of 15

1.86

1.46

0.0020

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0269

Exonuclease

3 of 11

1.99

1.9

0.00033

KW-0234

DNA repair

4 of 31

1.67

1.72

0.00024

KW-0227

DNA damage

4 of 31

1.67

1.72

0.00024

KW-0347

Helicase

3 of 20

1.73

1.5

0.0012

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF13361

UvrD-like helicase C-terminal domain

3 of 3

2.56

2.31

0.00013

PF12705

PD-(D/E)XK nuclease superfamily

3 of 4

2.43

2.28

0.00013

PF13245

AAA domain

2 of 5

2.16

0.99

0.0212

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR038726

PD-(D/E)XK endonuclease-like domain, AddAB-type

3 of 4

2.43

1.92

0.00058

IPR011604

PD-(D/E)XK endonuclease-like domain superfamily

3 of 4

2.43

1.92

0.00058

IPR011335

Restriction endonuclease type II-like

3 of 7

2.19

1.82

0.00067

IPR014016

UvrD-like helicase, ATP-binding domain

3 of 8

2.13

1.8

0.00068

IPR000212

DNA helicase, UvrD/REP type

3 of 8

2.13

1.8

0.00068

(more ...)

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