node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
WN55_00922 | WN55_01711 | A0A154PB88 | A0A154PGM7 | Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. | Acetyl-CoA acetyltransferase, mitochondrial; Belongs to the thiolase-like superfamily. Thiolase family. | 0.956 |
WN55_00922 | WN55_02310 | A0A154PB88 | A0A154PH89 | Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. | 3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. | 0.957 |
WN55_00922 | WN55_03975 | A0A154PB88 | A0A154PMC0 | Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. | Hydroxymethylglutaryl-CoA lyase, mitochondrial. | 0.974 |
WN55_00922 | WN55_07718 | A0A154PB88 | A0A154P623 | Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. | Methylglutaconyl-CoA hydratase, mitochondrial; Belongs to the enoyl-CoA hydratase/isomerase family. | 0.719 |
WN55_00922 | WN55_11205 | A0A154PB88 | A0A154P9W0 | Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. | Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial. | 0.567 |
WN55_00922 | WN55_11456 | A0A154PB88 | A0A154PAX3 | Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. | Trifunctional enzyme subunit beta, mitochondrial; Belongs to the thiolase-like superfamily. Thiolase family. | 0.897 |
WN55_01166 | WN55_01626 | A0A154PEB2 | A0A154PGB9 | Isocitrate dehydrogenase [NAD] subunit, mitochondrial. | Isocitrate dehydrogenase [NAD] subunit, mitochondrial. | 0.999 |
WN55_01166 | WN55_03975 | A0A154PEB2 | A0A154PMC0 | Isocitrate dehydrogenase [NAD] subunit, mitochondrial. | Hydroxymethylglutaryl-CoA lyase, mitochondrial. | 0.962 |
WN55_01166 | WN55_06777 | A0A154PEB2 | A0A154PQZ9 | Isocitrate dehydrogenase [NAD] subunit, mitochondrial. | Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 0.593 |
WN55_01166 | WN55_07047 | A0A154PEB2 | A0A154PRY6 | Isocitrate dehydrogenase [NAD] subunit, mitochondrial. | Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial. | 0.998 |
WN55_01166 | WN55_07718 | A0A154PEB2 | A0A154P623 | Isocitrate dehydrogenase [NAD] subunit, mitochondrial. | Methylglutaconyl-CoA hydratase, mitochondrial; Belongs to the enoyl-CoA hydratase/isomerase family. | 0.575 |
WN55_01626 | WN55_01166 | A0A154PGB9 | A0A154PEB2 | Isocitrate dehydrogenase [NAD] subunit, mitochondrial. | Isocitrate dehydrogenase [NAD] subunit, mitochondrial. | 0.999 |
WN55_01626 | WN55_03975 | A0A154PGB9 | A0A154PMC0 | Isocitrate dehydrogenase [NAD] subunit, mitochondrial. | Hydroxymethylglutaryl-CoA lyase, mitochondrial. | 0.962 |
WN55_01626 | WN55_06777 | A0A154PGB9 | A0A154PQZ9 | Isocitrate dehydrogenase [NAD] subunit, mitochondrial. | Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 0.593 |
WN55_01626 | WN55_07718 | A0A154PGB9 | A0A154P623 | Isocitrate dehydrogenase [NAD] subunit, mitochondrial. | Methylglutaconyl-CoA hydratase, mitochondrial; Belongs to the enoyl-CoA hydratase/isomerase family. | 0.434 |
WN55_01711 | WN55_00922 | A0A154PGM7 | A0A154PB88 | Acetyl-CoA acetyltransferase, mitochondrial; Belongs to the thiolase-like superfamily. Thiolase family. | Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. | 0.956 |
WN55_01711 | WN55_02310 | A0A154PGM7 | A0A154PH89 | Acetyl-CoA acetyltransferase, mitochondrial; Belongs to the thiolase-like superfamily. Thiolase family. | 3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. | 0.996 |
WN55_01711 | WN55_03975 | A0A154PGM7 | A0A154PMC0 | Acetyl-CoA acetyltransferase, mitochondrial; Belongs to the thiolase-like superfamily. Thiolase family. | Hydroxymethylglutaryl-CoA lyase, mitochondrial. | 0.956 |
WN55_01711 | WN55_07718 | A0A154PGM7 | A0A154P623 | Acetyl-CoA acetyltransferase, mitochondrial; Belongs to the thiolase-like superfamily. Thiolase family. | Methylglutaconyl-CoA hydratase, mitochondrial; Belongs to the enoyl-CoA hydratase/isomerase family. | 0.850 |
WN55_01711 | WN55_11205 | A0A154PGM7 | A0A154P9W0 | Acetyl-CoA acetyltransferase, mitochondrial; Belongs to the thiolase-like superfamily. Thiolase family. | Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial. | 0.826 |