serC protein (Eubacteriaceae bacterium CHKCI004)

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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Score

serC

Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (360 aa)

Predicted Functional Partners:

serA_2

0.998

yoaD

0.963

cysK

0.908

thrC

0.899

pheA_1

0.887

pheA_2

0.887

cysK1

0.843

serA_1

0.808

hprA

0.808

CVI73454.1

0.757

Your Current Organism:

Eubacteriaceae bacterium CHKCI004

NCBI taxonomy Id: 1780380
Other names: E. bacterium CHKCI004

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CVI73454.1	pheA_1	BN3660_03119	BN3660_00974	Hypothetical protein.	P-protein.	0.485
CVI73454.1	pheA_2	BN3660_03119	BN3660_01475	Hypothetical protein.	P-protein.	0.485
CVI73454.1	serA_2	BN3660_03119	BN3660_02889	Hypothetical protein.	D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.606
CVI73454.1	serC	BN3660_03119	BN3660_00309	Hypothetical protein.	Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine.	0.757
CVI73454.1	thrC	BN3660_03119	BN3660_02147	Hypothetical protein.	Threonine synthase.	0.680
CVI73454.1	yoaD	BN3660_03119	BN3660_01478	Hypothetical protein.	Putative 2-hydroxyacid dehydrogenase YoaD; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.606
cysK	serA_2	BN3660_00308	BN3660_02889	Cysteine synthase.	D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.413
cysK	serC	BN3660_00308	BN3660_00309	Cysteine synthase.	Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine.	0.908
cysK	yoaD	BN3660_00308	BN3660_01478	Cysteine synthase.	Putative 2-hydroxyacid dehydrogenase YoaD; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.413
cysK1	serA_2	BN3660_03682	BN3660_02889	O-acetylserine sulfhydrylase; Belongs to the cysteine synthase/cystathionine beta- synthase family.	D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.413
cysK1	serC	BN3660_03682	BN3660_00309	O-acetylserine sulfhydrylase; Belongs to the cysteine synthase/cystathionine beta- synthase family.	Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine.	0.843
cysK1	yoaD	BN3660_03682	BN3660_01478	O-acetylserine sulfhydrylase; Belongs to the cysteine synthase/cystathionine beta- synthase family.	Putative 2-hydroxyacid dehydrogenase YoaD; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.413
hprA	serA_2	BN3660_02045	BN3660_02889	Glycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.689
hprA	serC	BN3660_02045	BN3660_00309	Glycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine.	0.808
hprA	yoaD	BN3660_02045	BN3660_01478	Glycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Putative 2-hydroxyacid dehydrogenase YoaD; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.718
pheA_1	CVI73454.1	BN3660_00974	BN3660_03119	P-protein.	Hypothetical protein.	0.485
pheA_1	pheA_2	BN3660_00974	BN3660_01475	P-protein.	P-protein.	0.904
pheA_1	serC	BN3660_00974	BN3660_00309	P-protein.	Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine.	0.887
pheA_1	thrC	BN3660_00974	BN3660_02147	P-protein.	Threonine synthase.	0.431
pheA_2	CVI73454.1	BN3660_01475	BN3660_03119	P-protein.	Hypothetical protein.	0.485

page 1 of 3

Network Stats

number of nodes:

5

number of edges:

7

average node degree:

2.8

avg. local clustering coefficient:

0.9

expected number of edges:

5

PPI enrichment p-value:

0.255

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006351

Transcription, DNA-templated

6 of 16

2.18

3.97

4.08e-09

GO:0031564

Transcription antitermination

3 of 3

2.61

2.28

5.92e-05

GO:0006353

DNA-templated transcription, termination

3 of 4

2.48

2.24

6.48e-05

GO:0034654

Nucleobase-containing compound biosynthetic process

7 of 165

1.24

1.43

1.06e-05

GO:0010467

Gene expression

7 of 235

1.08

1.1

6.48e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003899

DNA-directed 5-3 RNA polymerase activity

3 of 9

2.13

1.41

0.0020

GO:0003676

Nucleic acid binding

7 of 589

0.68

0.42

0.0294

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000428

DNA-directed RNA polymerase complex

3 of 10

2.09

1.7

0.00048

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1641

Transcription, DNA-templated, and SNF2, N-terminal

6 of 14

2.24

4.22

1.51e-09

CL:1659

DNA-templated transcription, termination

3 of 5

2.39

2.19

7.37e-05

CL:1645

RNA polymerase

3 of 5

2.39

2.19

7.37e-05

CL:1417

Translation, and Purine nucleoside triphosphate biosynthetic process

7 of 126

1.35

1.73

2.49e-06

CL:1369

Mixed, incl. NAD(P)+ transhydrogenase activity, and NAD synthase

2 of 7

2.07

0.92

0.0188

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03020

RNA polymerase

3 of 5

2.39

2.18

7.51e-05

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-9635486

Infection with Mycobacterium tuberculosis

3 of 84

1.16

0.65

0.0270

MAP-5663205

Infectious disease

3 of 88

1.14

0.64

0.0270

MAP-1643685

Disease

3 of 93

1.12

0.63

0.0270

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0008023

Transcription elongation factor complex

2 of 2

2.61

1.11

0.0097

GOCC:0000428

DNA-directed RNA polymerase complex

3 of 50

1.39

0.74

0.0237

GOCC:0005622

Intracellular

10 of 1477

0.44

0.32

0.0179

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0889

Transcription antitermination

3 of 3

2.61

2.35

4.47e-05

KW-0240

DNA-directed RNA polymerase

3 of 6

2.31

2.19

6.59e-05

KW-0804

Transcription

6 of 123

1.3

1.41

4.47e-05

KW-0806

Transcription termination

2 of 3

2.43

1.37

0.0029

KW-0548

Nucleotidyltransferase

3 of 46

1.42

0.93

0.0082

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