Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ORW22087.1Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. (453 aa)    
Predicted Functional Partners:
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
 
 
 0.999
hemH
Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family.
 
 0.994
ORW22088.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.941
ORW26317.1
Magnesium chelatase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.933
ORW24191.1
Magnesium chelatase; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
 
 0.929
ORW16632.1
Coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family.
    
 0.824
ORW23453.1
Phosphoribosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
    0.753
ORW21153.1
Delta-aminolevulinic acid dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ALAD family.
 
 
 0.724
ORW21152.1
Bifunctional uroporphyrinogen-III C-methyltransferase/uroporphyrinogen-III synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.663
ORW16628.1
Sirohydrochlorin ferrochelatase; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.634
Your Current Organism:
Mycolicibacter nonchromogenicus
NCBI taxonomy Id: 1782
Other names: ATCC 19530, CCUG 28009, CIP 106811, DSM 44164, JCM 6364, M. nonchromogenicus, Mycobacterium nonchromogenicum, NCTC 10424
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