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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
co-expression
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[Homology]
Score
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (297 aa)    
Predicted Functional Partners:
PAE2868
Homoserine dehydrogenase; Amino acid biosynthesis; Aspartate family.
 
 0.997
PAE2878
Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine.
  
 
 0.994
PAE2420
Cystathionine gamma-synthase; Amino acid biosynthesis; Aspartate family.
  
 
 0.953
PAE2877
Aspartate kinase; Amino acid biosynthesis; Aspartate family.
 
 
 0.947
ilvE
Branched-chain amino acid aminotransferase (ilvE); Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
  
 
 0.896
PAE3655
5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Amino acid biosynthesis; Aspartate family.
 
 
 0.877
PAE2876
Aspartate-semialdehyde dehydrogenase (asd); Amino acid biosynthesis; Aspartate family.
 
  
 0.844
ahcY
Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
  
 
  0.821
ilvD
Dihydroxy-acid dehydratase (ilvD); Amino acid biosynthesis; Pyruvate family; Belongs to the IlvD/Edd family.
 
  
 0.783
PAE0036
Conserved hypothetical protein.
       0.775
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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