STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PAE0218Amidophosphoribosyltransferase (purF); Purines, pyrimidines, nucleosides, and nucleotides; Purine ribonucleotide biosynthesis. (378 aa)    
Predicted Functional Partners:
purD
Phosphoribosylglycinamide synthetase (GARS) (purD); Purines, pyrimidines, nucleosides, and nucleotides; Purine ribonucleotide biosynthesis; Belongs to the GARS family.
 
 0.999
PAE0221
Phosphoribosylformylglycinamidine cyclo-ligase (AIRS) (purM); Purines, pyrimidines, nucleosides, and nucleotides; Purine ribonucleotide biosynthesis.
 
  
 0.994
purQ
Phosphoribosylformylglycinamidine synthase I (FGAM synthase I) (purQ); Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL a [...]
 
 
 0.993
PAE0219
Phosphoribosylglycinamide formyltransferase; Purines, pyrimidines, nucleosides, and nucleotides; Purine ribonucleotide biosynthesis.
 
 
 0.988
carB
Carbamoyl-phosphate synthase large subunit; Purines, pyrimidines, nucleosides, and nucleotides; Pyrimidine ribonucleotide biosynthesis.
 
 
 0.978
purC
Phosphoribosylaminoimidazole-succinocarboxamide synthase (purC); Purines, pyrimidines, nucleosides, and nucleotides; Purine ribonucleotide biosynthesis; Belongs to the SAICAR synthetase family.
 
 
 0.975
carA
Carbamoyl-phosphate synthase small subunit; Purines, pyrimidines, nucleosides, and nucleotides; Pyrimidine ribonucleotide biosynthesis; Belongs to the CarA family.
 
 
 0.974
purE
Phosphoribosylaminoimidazole carboxylase catalytic subunit (AIRC) (purE); Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).
 
  
 0.957
PAE0226
Amidophosphoribosyltransferase (purF); Purines, pyrimidines, nucleosides, and nucleotides; Purine ribonucleotide biosynthesis; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
 
  
 
0.950
folD
Methylenetetrahydrofolate dehydrogenase (folD); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
  
  
 0.945
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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