Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
PAE0329Conserved hypothetical protein. (482 aa)    
Predicted Functional Partners:
PAE0331
Thiamine-binding periplasmic protein; Transport and binding proteins; Other.
 
 
 0.980
PAE0328
Transport and binding proteins; Other.
  
 
 0.839
PAE3657
Transport and binding proteins; Unknown substrate.
 
  
 0.768
PAE0061
Extracellular solute binding protein, conjectural; Transport and binding proteins; Anions.
 
  
 0.747
PAE2839
Molybdopterin oxidoreductase, molybdopterin binding subunit part 2, authentic frameshift; Energy metabolism; Electron transport.
 
     0.487
PAE1349
Rieske iron sulfur protein (parR); Energy metabolism; Electron transport.
 
     0.472
PAE0573
Conserved hypothetical protein.
  
    0.456
PAE1884
Phosphate permease, conjectural; Transport and binding proteins; Anions.
 
     0.456
thiC
Thiamine biosynthesis protein (thiC); Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family.
  
  
 0.435
PAE1636
Conserved hypothetical protein.
  
     0.413
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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