Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
PAE0342Hypothetical protein. (182 aa)    
Predicted Functional Partners:
PAE0343
Cobalamin biosynthesis putative precorrin-8X methylmutase (precorrin isomerase); Biosynthesis of cofactors, prosthetic groups, and carriers; Heme, porphyrin and cobalamin.
       0.792
PAE0344
Cobalamin biosynthesis precorrin-3 methylase (cbiF); Biosynthesis of cofactors, prosthetic groups, and carriers; Heme, porphyrin and cobalamin.
       0.792
cbiD
Cobalamin biosynthesis protein D (cbiD); Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.
       0.792
cbiT
Cobalamin biosynthesis precorrin-8W decarboxylase (cbiT); Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7.
       0.792
PAE0348
Cobalamin biosynthesis precorrin-3 methylase (cbiF); Biosynthesis of cofactors, prosthetic groups, and carriers; Heme, porphyrin and cobalamin; Belongs to the precorrin methyltransferase family.
       0.792
PAE0349
Cobalamin biosynthesis precorrin-3 methylase (cbiF); Biosynthesis of cofactors, prosthetic groups, and carriers; Heme, porphyrin and cobalamin; Belongs to the precorrin methyltransferase family.
       0.792
PAE0341
Hypothetical protein.
       0.639
PAE0339
Cobalamin biosynthesis protein G (cbiG); Biosynthesis of cofactors, prosthetic groups, and carriers; Heme, porphyrin and cobalamin.
       0.471
PAE0340
Cobalamin biosynthesis precorrin-6Y methylase (cbiE); Biosynthesis of cofactors, prosthetic groups, and carriers; Heme, porphyrin and cobalamin.
       0.471
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.