Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
PAE0370cob(I)alamin adenosyltransferase; Biosynthesis of cofactors, prosthetic groups, and carriers; Heme, porphyrin and cobalamin. (154 aa)    
Predicted Functional Partners:
PAE0381
Cobalamin biosynthesis protein B (cbiB); Biosynthesis of cofactors, prosthetic groups, and carriers; Heme, porphyrin and cobalamin.
 
  
 0.981
cobS
Cobalamin (5'-phosphate) synthase (cobS); Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family.
  
 
 0.972
PAE2587
Cobyrinic acid a,c-diamide synthase (cbiA) part 2, authentic frameshift; Biosynthesis of cofactors, prosthetic groups, and carriers; Heme, porphyrin and cobalamin.
 
 
 0.969
PAE0372
Conserved hypothetical protein; Belongs to the UPF0284 family.
     
 0.820
PAE3155
Ribonucleotide reductase; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.
 
   
 0.799
PAE0371
Conserved hypothetical protein.
       0.712
PAE0377
cobC aminotransferase, conjectural; Biosynthesis of cofactors, prosthetic groups, and carriers; Heme, porphyrin and cobalamin.
 
   
 0.628
PAE0343
Cobalamin biosynthesis putative precorrin-8X methylmutase (precorrin isomerase); Biosynthesis of cofactors, prosthetic groups, and carriers; Heme, porphyrin and cobalamin.
 
   
 0.588
PAE0348
Cobalamin biosynthesis precorrin-3 methylase (cbiF); Biosynthesis of cofactors, prosthetic groups, and carriers; Heme, porphyrin and cobalamin; Belongs to the precorrin methyltransferase family.
 
   
 0.565
cbiT
Cobalamin biosynthesis precorrin-8W decarboxylase (cbiT); Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7.
 
   
 0.546
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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