STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
trpCIndole-3-glycerol-phosphate synthase; Amino acid biosynthesis; Aromatic amino acid family; Belongs to the TrpC family. (249 aa)    
Predicted Functional Partners:
PAE2458
Tryptophan synthase alpha subunit; Amino acid biosynthesis; Aromatic amino acid family.
 
 
 0.999
PAE2459
Anthranilate synthase component II; Amino acid biosynthesis; Aromatic amino acid family.
  
 0.999
trpF
Phosphoribosyl anthranilate isomerase; Amino acid biosynthesis; Aromatic amino acid family; Belongs to the TrpF family.
 
 
 0.999
trpD
Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA).
 
  
 0.997
PAE2460
Anthranilate synthase component I; Amino acid biosynthesis; Aromatic amino acid family.
 
 0.995
trpB
Tryptophan synthase beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
 
 
 0.962
PAE2777
Hypothetical protein.
  
 
 0.962
PAE0257
Tryptophan synthase beta subunit (trpB), authentic frameshift; Amino acid biosynthesis; Aromatic amino acid family.
 
 
 0.959
PAE0568
Cation efflux system protein, conjectural; Transport and binding proteins; Cations.
  
  
 0.791
hisG
ATP phosphoribosyltransferase (hisG); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
 
  
 0.731
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.