Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
PAE0586Hypothetical; Conserved within genome. (59 aa)    
Predicted Functional Partners:
PAE0585
Siroheme synthesis protein, conjectural; Biosynthesis of cofactors, prosthetic groups, and carriers; Heme, porphyrin and cobalamin.
       0.706
PAE0583
Porphobilinogen synthase (delta-aminolevulinic acid dehydratase) (hemB); Biosynthesis of cofactors, prosthetic groups, and carriers; Heme, porphyrin and cobalamin; Belongs to the ALAD family.
       0.700
PAE0589
Hypothetical protein.
       0.667
PAE0590
uroporphyrin-III C-methyltransferase; Biosynthesis of cofactors, prosthetic groups, and carriers; Heme, porphyrin and cobalamin; Belongs to the precorrin methyltransferase family.
       0.667
hemL
Glutamate-1-semialdehyde aminotransferase (hemL); Biosynthesis of cofactors, prosthetic groups, and carriers; Heme, porphyrin and cobalamin; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
       0.429
PAE0596
Biosynthesis of cofactors, prosthetic groups, and carriers; Other.
       0.429
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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