Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
PAE0696AAA family ATPase, possible cell division control protein cdc48; Cellular processes; Cell division. (731 aa)    
Predicted Functional Partners:
fen
DNA endonuclease rad2 homolog; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) [...]
 
 
 0.950
PAE3171
AAA family ATPase, possible cell division control protein cdc48; Cellular processes; Cell division.
  
  
 
0.901
PAE2981
Acetylpolyamine aminohydrolase, putative; Energy metabolism; Amino acids and amines.
 
 
 0.892
ef1b
Translation elongation factor aEF-1 beta subunit; Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.
     
 0.887
PAE0891
Hypothetical protein.
   
 0.870
PAE1861
Hypothetical protein with 4 ankyrin repeats; Unclassified.
   
 0.869
rpl40e
Protein synthesis; Ribosomal proteins: synthesis and modification; Belongs to the eukaryotic ribosomal protein eL40 family.
   
 0.863
PAE0692
Hypothetical protein with partial (eukaryotic) protein kinase domain; Unclassified.
   
 0.832
PAE0815
Serine/threonine protein kinase, putative; Regulatory functions; General.
   
 0.832
PAE0694
Conserved hypothetical protein.
       0.827
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.