STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
PAE0779Conserved hypothetical protein. (238 aa)    
Predicted Functional Partners:
tfe
Conserved hypothetical protein; Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes [...]
       0.917
PAE0783
Conserved helix-turn-helix protein; Unclassified.
 
     0.878
hflX
Conserved protein (possible hflX); GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
       0.845
PAE0786
Conserved protein with predicted RNA binding PUA domain; Unclassified.
       0.794
PAE0678
Conserved hypothetical protein.
  
     0.619
PAE0385
Metal ion binding transcriptional regulator, conjectural; Regulatory functions; General.
  
     0.530
psmA
Proteasome alpha subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
    
 
 0.515
PAE0284
Conserved hypothetical protein.
  
     0.500
PAE3030
Oligosaccharyl transferase STT3 homolog; Protein fate; Protein modification and repair.
  
     0.498
PAE1659
C-5 cytosine-specific DNA methylase; DNA metabolism; DNA replication, recombination, and repair; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
       0.496
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.