Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
moaAMolybdenum cofactor biosynthesis protein (moaA); Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate; Belongs to the radical SAM superfamily. MoaA family. (310 aa)    
Predicted Functional Partners:
moaC
Molybdenum cofactor biosynthesis protein (moaC); Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family.
 
 
 0.998
PAE0727
Molybdenum cofactor biosynthesis protein D/E; Biosynthesis of cofactors, prosthetic groups, and carriers; Molybdopterin.
 
  
 0.987
folE
GTP cyclohydrolase I; Biosynthesis of cofactors, prosthetic groups, and carriers; Folic acid.
  
 
 0.937
PAE0969
Molybdenum cofactor biosynthesis protein (moaB); Biosynthesis of cofactors, prosthetic groups, and carriers; Molybdopterin.
 
  
 0.911
PAE3466
Molybdenum cofactor biosynthesis protein (moaA); Biosynthesis of cofactors, prosthetic groups, and carriers; Molybdopterin.
 
 0.900
PAE3048
Molybdenum cofactor biosynthesis protein (moaA); Biosynthesis of cofactors, prosthetic groups, and carriers; Molybdopterin.
 
 0.850
PAE3465
Molybdenum cofactor biosynthesis protein (moaA); Biosynthesis of cofactors, prosthetic groups, and carriers; Molybdopterin.
 
 0.836
PAE0252
Diadenosine 5'5'''-P1,P4-tetraphosphate pyrophosphohydrolase (mutT/nudix family protein); DNA metabolism; DNA replication, recombination, and repair.
  
 
 0.829
PAE0714
Diadenosine 5'5'''-P1,P4-tetraphosphate pyrophosphohydrolase (mutT/nudix family protein); DNA metabolism; DNA replication, recombination, and repair.
  
 
 0.829
PAE0832
Adenylate cyclase; Purines, pyrimidines, nucleosides, and nucleotides; Purine ribonucleotide biosynthesis.
    
  0.817
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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