Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
PAE0816Conserved protein with Forkhead-associated (FHA) domain; Unclassified. (150 aa)    
Predicted Functional Partners:
PAE0815
Serine/threonine protein kinase, putative; Regulatory functions; General.
 
 
 
 0.858
PAE2648
Pyruvate dehydrogenase E2 (dihydrolipoamide acetyltransferase); Energy metabolism; Glycolysis/gluconeogenesis.
  
 
 0.794
rps2
Protein synthesis; Ribosomal proteins: synthesis and modification; Belongs to the universal ribosomal protein uS2 family.
   
   0.777
PAE2004
Serine/threonine specific protein phosphatase; Regulatory functions; General.
 
 
 0.758
pcn2
Proliferating-cell nuclear antigen homolog (PCNA); Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family.
   
 
 0.678
pcn1
Proliferating-cell nuclear antigen homolog (PCNA); Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family.
   
 
 0.678
PAE0818
Conserved hypothetical protein; Belongs to the MEMO1 family.
       0.666
PAE2280
Conserved hypothetical protein.
 
 
 0.615
PAE2904
Exonuclease sbcD, conjectural; DNA metabolism; DNA replication, recombination, and repair.
  
 
 0.594
PAE2905
Purine NTPase, probable; Unclassified.
   
 0.545
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.