Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
pykPyruvate kinase; Energy metabolism; Glycolysis/gluconeogenesis; Belongs to the pyruvate kinase family. (461 aa)    
Predicted Functional Partners:
eno
Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family.
 
 0.995
PAE1610
Glucose-6-phosphate isomerase, conjectural; Catalyzes the isomerization of both glucose 6-phosphate and epimeric mannose 6-phosphate at a similar catalytic efficiency.
  
 0.985
PAE1688
Malate oxidoreductase (mae); Energy metabolism; Other.
  
 0.960
pgk
Phosphoglycerate kinase; Energy metabolism; Glycolysis/gluconeogenesis; Belongs to the phosphoglycerate kinase family.
 
 
 0.957
PAE2423
Phosphoenolpyruvate synthase (pyruvate,water dikinase); Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family.
    
 0.948
PAE3383
Pyruvate, phosphate dikinase; Energy metabolism; Other.
    
 0.947
ppcA
Conserved hypothetical protein; Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. Belongs to the PEPCase type 2 family.
     
 0.945
rpl6
Ribosomal protein L6; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family.
 
 
 0.944
gap
Glyceraldehyde-3-phosphate dehydrogenase; Energy metabolism; Glycolysis/gluconeogenesis.
 
 
 0.940
mdh
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily.
  
 0.939
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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