Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
PAE0870Conserved NAD/P oxidoreductase; Unclassified. (310 aa)    
Predicted Functional Partners:
PAE2053
Pleiotropic regulatory protein, conjectural; Regulatory functions; General; Belongs to the DegT/DnrJ/EryC1 family.
 
  
 0.910
PAE3281
UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase, conjectural; Cell envelope; Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.
 
  
 0.860
lysS
lysyl-tRNA synthetase; Protein synthesis; tRNA aminoacylation; Belongs to the class-II aminoacyl-tRNA synthetase family.
  
    0.831
PAE1185
Galactokinase; Energy metabolism; Sugars.
  
 
 0.823
PAE1472
Acetyl/acyl transferase related protein; Fatty acid and phospholipid metabolism; Biosynthesis.
 
  
 0.816
PAE0868
Hypothetical protein.
       0.792
PAE0867
Conserved hypothetical protein.
  
    0.743
PAE0866
Conserved hypothetical protein.
       0.729
hisD
Histidinol dehydrogenase (hisD); Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
  
 
 0.687
PAE0871
Hypothetical protein.
       0.623
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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