STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PAE0880DNA-(apurinic or apyrimidinic site) lyase (endonuclease III, PaNth); DNA metabolism; DNA replication, recombination, and repair. (223 aa)    
Predicted Functional Partners:
PAE3257
DNA-(apurinic or apyrimidinic site) lyase (endonuclease IV); DNA metabolism; DNA replication, recombination, and repair.
  
 
 0.865
fen
DNA endonuclease rad2 homolog; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) [...]
  
 
 0.706
PAE3199
U/G & T/G mismatch specific glycosylase (Pa-MIG); DNA glycosylase that excises thymine from T/G mismatches and uracil from U/G mismatches. Can also process T/GO and U/GO, but not A/G, T/C and U/C. Has weak AP lyase activity.
 
  
0.674
PAE2795
Serine protease; Protein fate; Degradation of proteins, peptides, and glycopeptides.
 
 
 
 0.655
PAE2458
Tryptophan synthase alpha subunit; Amino acid biosynthesis; Aromatic amino acid family.
  
    0.653
PAE1629
Adenylate kinase, conjectural; Purines, pyrimidines, nucleosides, and nucleotides; Nucleotide and nucleoside interconversions; Belongs to the UPF0200 family.
  
    0.646
PAE0879
Conserved hypothetical protein.
       0.644
ogt
methylated-DNA--[protein]-cysteine S-methyltransferase (ogt); Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
 
   
 0.590
PAE0882
Conserved hypothetical protein.
       0.581
rnhB
Ribonuclease HII (rnhB); Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family.
 
  
 0.549
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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