STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PAE0891Hypothetical protein. (269 aa)    
Predicted Functional Partners:
PAE3196
Hypothetical protein.
   
 0.863
rpl40e
Protein synthesis; Ribosomal proteins: synthesis and modification; Belongs to the eukaryotic ribosomal protein eL40 family.
    
  0.785
PAE0696
AAA family ATPase, possible cell division control protein cdc48; Cellular processes; Cell division.
   
 0.751
PAE3171
AAA family ATPase, possible cell division control protein cdc48; Cellular processes; Cell division.
   
 0.751
PAE1861
Hypothetical protein with 4 ankyrin repeats; Unclassified.
   
 0.729
PAE1693
TBP-interacting protein TIP49; Transcription; Transcription factors.
    
 0.728
PAE3320
D-3-phosphoglycerate dehydrogenase (serA); Amino acid biosynthesis; Serine family; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
   
 0.695
cobB1
Conserved hypothetical protein; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription; Belongs to the sirtuin family. Class U subfamily.
   
 
 0.656
cobB2
Conserved hypothetical protein; NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription. Belongs to the sirtuin family. Class III subfamily.
   
 
 0.656
PAE1878
ATP binding protein, degenerate; Transport and binding proteins; Unknown substrate.
  
 0.570
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.