STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PAE0893Chorismate mutase/prephenate dehydratase (P-protein); Amino acid biosynthesis; Aromatic amino acid family. (314 aa)    
Predicted Functional Partners:
PAE1941
Chorismate mutase, conjectural; Amino acid biosynthesis; Aromatic amino acid family.
 
 
 0.967
PAE1932
Phospho-2-dehydro-3-deoxyheptonate aldolase; Amino acid biosynthesis; Aromatic amino acid family.
 
  
 0.955
PAE0377
cobC aminotransferase, conjectural; Biosynthesis of cofactors, prosthetic groups, and carriers; Heme, porphyrin and cobalamin.
 
 
 0.940
PAE0918
Histidinol-phosphate aminotransferase (hisC); Amino acid biosynthesis; Histidine family.
 
 
 0.939
PAE0958
Histidinol-phosphate aminotransferase (hisC); Amino acid biosynthesis; Histidine family.
  
 
 0.930
PAE1964
Aspartate aminotransferase (aspC), conjectural; Amino acid biosynthesis; Aspartate family.
  
 
 0.924
PAE2251
Aspartate aminotransferase (aspC), conjectural; Amino acid biosynthesis; Aspartate family.
  
 
 0.924
thiI
Thiamine biosynthesis protein (thiI), probable; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
     
 0.766
aroC
Chorismate synthase (aroC); Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
 
   
 0.752
PAE1924
3-phosphoshikimate 1-carboxyvinyltransferase (aroA); Amino acid biosynthesis; Aromatic amino acid family.
 
  
 0.748
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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