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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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[Homology]
Score
PAE0918Histidinol-phosphate aminotransferase (hisC); Amino acid biosynthesis; Histidine family. (329 aa)    
Predicted Functional Partners:
hisB
Imidazoleglycerol-phosphate dehydratase; Amino acid biosynthesis; Histidine family.
 
 0.998
hisD
Histidinol dehydrogenase (hisD); Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
  
 0.973
PAE0893
Chorismate mutase/prephenate dehydratase (P-protein); Amino acid biosynthesis; Aromatic amino acid family.
 
 
 0.937
PAE2251
Aspartate aminotransferase (aspC), conjectural; Amino acid biosynthesis; Aspartate family.
 
 
 0.931
PAE0958
Histidinol-phosphate aminotransferase (hisC); Amino acid biosynthesis; Histidine family.
  
  
 
0.927
PAE1964
Aspartate aminotransferase (aspC), conjectural; Amino acid biosynthesis; Aspartate family.
 
 
0.927
hisH
Amidotransferase (hisH); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
 
  
 0.919
PAE1941
Chorismate mutase, conjectural; Amino acid biosynthesis; Aromatic amino acid family.
    
 0.915
hisF
Histidine biosynthesis protein (hisF,cyclase); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
 
  
 0.912
hisG
ATP phosphoribosyltransferase (hisG); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
 
  
 0.907
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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