STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Experiments
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[Homology]
Score
PAE09392-oxoacid ferredoxin oxidoreductase alpha subunit; Energy metabolism; Electron transport. (633 aa)    
Predicted Functional Partners:
PAE0938
2-oxoacid ferredoxin oxidoreductase beta subunit; Energy metabolism; Electron transport.
 
 0.998
PAE2737
2-oxoacid ferredoxin oxidoreductase beta subunit; Energy metabolism; Electron transport.
 
 0.995
PAE1558
2-oxoacid ferredoxin oxidoreductase beta subunit; Energy metabolism; Electron transport.
 
 0.994
PAE3250
Conserved hypothetical protein.
  
 0.935
PAE3249
Conserved hypothetical protein.
  
 0.933
PAE3300
Acetolactate synthase large subunit (ilvB); Amino acid biosynthesis; Pyruvate family.
  
 
 0.922
sucC
succinyl-CoA synthetase beta subunit (sucC); Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
    
 0.919
sucD
succinyl-CoA synthetase alpha subunit (sucD); Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
    
 0.919
PAE1559
2-oxoacid ferredoxin oxidoreductase alpha subunit; Energy metabolism; Electron transport.
  
  
 
0.918
PAE1651
Isocitrate dehydrogenase; Energy metabolism; TCA cycle.
  
 
 0.918
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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