STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PAE0949Hydrogenase expression/formation protein HypE; Protein fate; Protein modification and repair. (326 aa)    
Predicted Functional Partners:
PAE0951
Aminotransferase, conjectural; Unclassified.
       0.580
PAE0952
Conserved hypothetical protein; Belongs to the UPF0215 family.
       0.559
PAE0953
Putrescine/spermidine binding protein, conjectural; Transport and binding proteins; Amino acids, peptides and amines.
       0.552
PAE1580
NADH-ubiquinone oxidoreductase subunit; Energy metabolism; Electron transport.
  
  
 0.518
PAE2926
NADH-ubiquinone oxidoreductase subunit; Energy metabolism; Electron transport.
     
 0.460
PAE0221
Phosphoribosylformylglycinamidine cyclo-ligase (AIRS) (purM); Purines, pyrimidines, nucleosides, and nucleotides; Purine ribonucleotide biosynthesis.
    
 
 0.436
PAE2365
Nucleoside-triphosphatase (NTPase); Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
 
     0.435
PAE1568
NADH-ubiquinone oxidoreductase subunit; Energy metabolism; Electron transport.
     
 0.415
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.