Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
PAE0949Hydrogenase expression/formation protein HypE; Protein fate; Protein modification and repair. (326 aa)    
Predicted Functional Partners:
PAE0951
Aminotransferase, conjectural; Unclassified.
       0.580
PAE0952
Conserved hypothetical protein; Belongs to the UPF0215 family.
       0.559
PAE0953
Putrescine/spermidine binding protein, conjectural; Transport and binding proteins; Amino acids, peptides and amines.
       0.553
PAE3655
5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Amino acid biosynthesis; Aspartate family.
     
 0.551
PAE2020
Conserved hypothetical protein.
       0.464
PAE0727
Molybdenum cofactor biosynthesis protein D/E; Biosynthesis of cofactors, prosthetic groups, and carriers; Molybdopterin.
     
 0.446
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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