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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PAE0972Adenylosuccinate lyase (purB); Purines, pyrimidines, nucleosides, and nucleotides; Purine ribonucleotide biosynthesis. (403 aa)    
Predicted Functional Partners:
purC
Phosphoribosylaminoimidazole-succinocarboxamide synthase (purC); Purines, pyrimidines, nucleosides, and nucleotides; Purine ribonucleotide biosynthesis; Belongs to the SAICAR synthetase family.
 0.999
purA
Adenylosuccinate synthetase (purA); Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
 
 0.999
purD
Phosphoribosylglycinamide synthetase (GARS) (purD); Purines, pyrimidines, nucleosides, and nucleotides; Purine ribonucleotide biosynthesis; Belongs to the GARS family.
  
 
 0.992
purL
Phosphoribosylformylglycinamidine synthase II (FGAM synthase II) (purL); Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL [...]
 
  
 0.991
purK
Phosphoribosylaminoimidazole carboxylase ATPase subunit (AIRC) (purK); Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR); Belongs to the PurK/PurT family.
  
  
 0.991
purE
Phosphoribosylaminoimidazole carboxylase catalytic subunit (AIRC) (purE); Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).
  
  
 0.990
PAE0221
Phosphoribosylformylglycinamidine cyclo-ligase (AIRS) (purM); Purines, pyrimidines, nucleosides, and nucleotides; Purine ribonucleotide biosynthesis.
  
 
 0.988
purQ
Phosphoribosylformylglycinamidine synthase I (FGAM synthase I) (purQ); Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL a [...]
 
  
 0.983
PAE2071
Phosphoribosyl transferase; Unclassified.
  
 0.979
PAE0219
Phosphoribosylglycinamide formyltransferase; Purines, pyrimidines, nucleosides, and nucleotides; Purine ribonucleotide biosynthesis.
  
 
 0.977
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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