Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
PAE1105Conserved hypothetical protein. (119 aa)    
Predicted Functional Partners:
PAE1106
Conserved hypothetical protein.
       0.792
cobS
Cobalamin (5'-phosphate) synthase (cobS); Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family.
  
    0.771
leuS
leucyl-tRNA synthetase; Protein synthesis; tRNA aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family.
       0.675
PAE0749
Conserved protein (nfeD homolog); Unclassified.
  
  
 0.595
PAE2539
Conserved hypothetical protein.
  
  
 0.595
PAE0344
Cobalamin biosynthesis precorrin-3 methylase (cbiF); Biosynthesis of cofactors, prosthetic groups, and carriers; Heme, porphyrin and cobalamin.
  
    0.532
PAE1103
P. aerophilum family 453, possible regulatory protein; Regulatory functions; General.
       0.525
PAE0262
Prohibitin homolog (hflK family); Unclassified.
  
 
 0.499
PAE0750
Conserved protein (band 7 homolog); Unclassified.
  
 
 0.499
cbiD
Cobalamin biosynthesis protein D (cbiD); Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.
  
    0.424
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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