STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PAE11752-hydroxyacid dehydrogenase; Unclassified; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (301 aa)    
Predicted Functional Partners:
PAE1176
Hypothetical protein.
       0.752
PAE1173
Conserved hypothetical protein.
       0.714
PAE1177
Hypothetical protein.
       0.618
pyk
Pyruvate kinase; Energy metabolism; Glycolysis/gluconeogenesis; Belongs to the pyruvate kinase family.
 
 
 0.592
rpl4
Ribosomal protein L4; One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
  
 
 0.538
PAE1171
Conserved hypothetical protein.
       0.527
pyrE
Orotate phosphoribosyltransferase (pyrE); Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
 
 
 0.517
PAE2832
Short chain dehydrogenase; Unclassified.
 
 
 0.489
PAE0764
Phosphomannomutase (pmm); Cell envelope; Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides; Belongs to the phosphohexose mutase family.
 
 
 0.488
mdh
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily.
  
 
 0.486
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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