| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| PAE1204 | pyrG | PAE1204 | PAE3518 | Pantothenate metabolism flavoprotein (dfp); DNA metabolism; DNA replication, recombination, and repair. | CTP synthase (pyrG); Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.417 |
| PAE1204 | speE | PAE1204 | PAE1203 | Pantothenate metabolism flavoprotein (dfp); DNA metabolism; DNA replication, recombination, and repair. | Spermidine synthase; Involved in the biosynthesis of polyamines which are thought to support the growth of thermophilic microorganisms under high- temperature conditions. It seems that long-chain and branched-chain of polyamines effectively stabilize DNA and RNA, respectively. Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to norspermidine and 1,3- diaminopropane to yield norspermine, and to spermidine to yield thermospermine. It can also synthesize thermospermine from putrescine (1,4-diaminobutane) and caldop [...] | 0.796 |
| PAE1476 | mtnP | PAE1476 | PAE3338 | Purines, pyrimidines, nucleosides, and nucleotides; Salvage of nucleosides and nucleotides. | Purine nucleoside phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. | 0.950 |
| PAE1476 | speE | PAE1476 | PAE1203 | Purines, pyrimidines, nucleosides, and nucleotides; Salvage of nucleosides and nucleotides. | Spermidine synthase; Involved in the biosynthesis of polyamines which are thought to support the growth of thermophilic microorganisms under high- temperature conditions. It seems that long-chain and branched-chain of polyamines effectively stabilize DNA and RNA, respectively. Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to norspermidine and 1,3- diaminopropane to yield norspermine, and to spermidine to yield thermospermine. It can also synthesize thermospermine from putrescine (1,4-diaminobutane) and caldop [...] | 0.900 |
| PAE1749 | speE | PAE1749 | PAE1203 | Conserved hypothetical protein; Specifically catalyzes the decarboxylation of L-arginine to agmatine. Has no S-adenosylmethionine decarboxylase (AdoMetDC) activity; Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily. | Spermidine synthase; Involved in the biosynthesis of polyamines which are thought to support the growth of thermophilic microorganisms under high- temperature conditions. It seems that long-chain and branched-chain of polyamines effectively stabilize DNA and RNA, respectively. Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to norspermidine and 1,3- diaminopropane to yield norspermine, and to spermidine to yield thermospermine. It can also synthesize thermospermine from putrescine (1,4-diaminobutane) and caldop [...] | 0.990 |
| PAE1749 | speH | PAE1749 | PAE1490 | Conserved hypothetical protein; Specifically catalyzes the decarboxylation of L-arginine to agmatine. Has no S-adenosylmethionine decarboxylase (AdoMetDC) activity; Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily. | Conserved hypothetical protein; Catalyzes the decarboxylation of S-adenosylmethionine to S- adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine; Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily. | 0.903 |
| PAE2260 | speE | PAE2260 | PAE1203 | Agmatinase (speB); Central intermediary metabolism; Polyamine biosynthesis; Belongs to the arginase family. | Spermidine synthase; Involved in the biosynthesis of polyamines which are thought to support the growth of thermophilic microorganisms under high- temperature conditions. It seems that long-chain and branched-chain of polyamines effectively stabilize DNA and RNA, respectively. Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to norspermidine and 1,3- diaminopropane to yield norspermine, and to spermidine to yield thermospermine. It can also synthesize thermospermine from putrescine (1,4-diaminobutane) and caldop [...] | 0.981 |
| ef1b | nac | PAE0695 | PAE3566 | Translation elongation factor aEF-1 beta subunit; Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA. | Conserved hypothetical protein; Contacts the emerging nascent chain on the ribosome. Belongs to the NAC-alpha family. | 0.863 |
| ef1b | rps10 | PAE0695 | PAE2907 | Translation elongation factor aEF-1 beta subunit; Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA. | Ribosomal protein S10; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. | 0.899 |
| ef1b | speE | PAE0695 | PAE1203 | Translation elongation factor aEF-1 beta subunit; Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA. | Spermidine synthase; Involved in the biosynthesis of polyamines which are thought to support the growth of thermophilic microorganisms under high- temperature conditions. It seems that long-chain and branched-chain of polyamines effectively stabilize DNA and RNA, respectively. Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to norspermidine and 1,3- diaminopropane to yield norspermine, and to spermidine to yield thermospermine. It can also synthesize thermospermine from putrescine (1,4-diaminobutane) and caldop [...] | 0.609 |
| mtnP | PAE1476 | PAE3338 | PAE1476 | Purine nucleoside phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. | Purines, pyrimidines, nucleosides, and nucleotides; Salvage of nucleosides and nucleotides. | 0.950 |
| mtnP | speE | PAE3338 | PAE1203 | Purine nucleoside phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. | Spermidine synthase; Involved in the biosynthesis of polyamines which are thought to support the growth of thermophilic microorganisms under high- temperature conditions. It seems that long-chain and branched-chain of polyamines effectively stabilize DNA and RNA, respectively. Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to norspermidine and 1,3- diaminopropane to yield norspermine, and to spermidine to yield thermospermine. It can also synthesize thermospermine from putrescine (1,4-diaminobutane) and caldop [...] | 0.946 |
| nac | ef1b | PAE3566 | PAE0695 | Conserved hypothetical protein; Contacts the emerging nascent chain on the ribosome. Belongs to the NAC-alpha family. | Translation elongation factor aEF-1 beta subunit; Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA. | 0.863 |
| nac | rps10 | PAE3566 | PAE2907 | Conserved hypothetical protein; Contacts the emerging nascent chain on the ribosome. Belongs to the NAC-alpha family. | Ribosomal protein S10; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. | 0.958 |
| nac | speE | PAE3566 | PAE1203 | Conserved hypothetical protein; Contacts the emerging nascent chain on the ribosome. Belongs to the NAC-alpha family. | Spermidine synthase; Involved in the biosynthesis of polyamines which are thought to support the growth of thermophilic microorganisms under high- temperature conditions. It seems that long-chain and branched-chain of polyamines effectively stabilize DNA and RNA, respectively. Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to norspermidine and 1,3- diaminopropane to yield norspermine, and to spermidine to yield thermospermine. It can also synthesize thermospermine from putrescine (1,4-diaminobutane) and caldop [...] | 0.643 |
| pyrG | PAE1204 | PAE3518 | PAE1204 | CTP synthase (pyrG); Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | Pantothenate metabolism flavoprotein (dfp); DNA metabolism; DNA replication, recombination, and repair. | 0.417 |
| pyrG | rps10 | PAE3518 | PAE2907 | CTP synthase (pyrG); Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | Ribosomal protein S10; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. | 0.716 |
| pyrG | speE | PAE3518 | PAE1203 | CTP synthase (pyrG); Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | Spermidine synthase; Involved in the biosynthesis of polyamines which are thought to support the growth of thermophilic microorganisms under high- temperature conditions. It seems that long-chain and branched-chain of polyamines effectively stabilize DNA and RNA, respectively. Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to norspermidine and 1,3- diaminopropane to yield norspermine, and to spermidine to yield thermospermine. It can also synthesize thermospermine from putrescine (1,4-diaminobutane) and caldop [...] | 0.643 |
| rps10 | ef1b | PAE2907 | PAE0695 | Ribosomal protein S10; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. | Translation elongation factor aEF-1 beta subunit; Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA. | 0.899 |
| rps10 | nac | PAE2907 | PAE3566 | Ribosomal protein S10; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. | Conserved hypothetical protein; Contacts the emerging nascent chain on the ribosome. Belongs to the NAC-alpha family. | 0.958 |
