Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
PAE1244Translation initiation factor aIF-2B subunit, conjectural; Protein synthesis; Translation factors. (259 aa)    
Predicted Functional Partners:
eif2a
Translation initiation factor aIF-2 alpha subunit; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-alpha family.
   
 0.970
PAE0064
Translation initiation factor aIF-2 gamma subunit, putative; Protein synthesis; Translation factors.
   
 0.917
PAE1764
GTP-binding protein; Unclassified.
   
 0.917
PAE0837
Sugar-phosphate nucleotidyl transferase; Unclassified.
   
 0.864
PAE2361
Sugar phospate transferase; Unclassified.
   
 0.864
PAE2968
Sugar-phosphate nucleotidyl transferase, putative; Energy metabolism; Biosynthesis and degradation of polysaccharides.
   
 0.864
PAE3024
Sugar-phosphate nucleotidyl transferase; Energy metabolism; Biosynthesis and degradation of polysaccharides.
   
 0.864
PAE3430
Glucose-1-phosphate adenylyltransferase; Energy metabolism; Biosynthesis and degradation of polysaccharides.
   
 0.864
PAE3554
Mannose-1-phosphate guanyltransferase; Purines, pyrimidines, nucleosides, and nucleotides; Sugar-nucleotide biosynthesis and conversions.
   
 0.864
PAE1242
Hypothetical protein.
       0.763
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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