Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
PAE1266Conserved hypothetical protein. (200 aa)    
Predicted Functional Partners:
guaA
GMP synthetase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP.
       0.638
PAE1263
Molybdopterin oxidoreductase, iron-sulfur binding subunit; Energy metabolism; Electron transport.
       0.621
PAE1265
Molybdopterin oxidoreductase, molybdopterin binding subunit; Energy metabolism; Electron transport.
       0.619
PAE1264
Conserved hypothetical protein.
       0.615
PAE3468
Conserved hypothetical protein.
  
   
 0.610
PAE2734
Rieske iron sulfur protein, putative; Energy metabolism; Electron transport.
  
     0.559
PAE2355
Glycosyl transferase; Unclassified.
 
     0.550
PAE2449
Conserved hypothetical protein.
 
     0.518
PAE1627
Hypothetical protein.
 
     0.507
PAE2994
Conserved hypothetical protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family.
  
     0.494
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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