Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
PAE1309Conserved hypothetical protein. (445 aa)    
Predicted Functional Partners:
PAE1038
D-3-phosphoglycerate dehydrogenase (serA); Amino acid biosynthesis; Serine family; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
 
 0.948
eno
Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family.
    
 0.946
pyk
Pyruvate kinase; Energy metabolism; Glycolysis/gluconeogenesis; Belongs to the pyruvate kinase family.
 
 
 0.926
PAE1145
Conserved protein (3-hydroxyisobutyrate dehydrogenase family); Unclassified.
  
 
 0.919
PAE2480
Aldehyde dehydrogenase; Unclassified.
  
 
 0.917
PAE0622
Aldehyde ferredoxin oxidoreductase (aor); Energy metabolism; Fermentation.
     
  0.900
PAE2052
Aldehyde ferredoxin oxidoreductase (aor); Energy metabolism; Fermentation.
     
  0.900
apgM
Phosphonopyruvate decarboxylase, conjectural; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate.
     
  0.900
PAE3427
Aldehyde ferredoxin oxidoreductase (aor); Energy metabolism; Fermentation.
     
  0.900
PAE1610
Glucose-6-phosphate isomerase, conjectural; Catalyzes the isomerization of both glucose 6-phosphate and epimeric mannose 6-phosphate at a similar catalytic efficiency.
    
 0.832
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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